{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:02:26Z","timestamp":1790467346935,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007313","name":"The University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA100632"],"award-info":[{"award-number":["CA100632"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>All\u2010trans retinoic acid (ATRA) and arsenic trioxide (ATO) combinations have produced excellent outcomes in patients with standard\u2010risk acute promyelocytic leukemia (APL). Herein, the authors update their long\u2010term results with the regimen of ATO\u2010ATRA and gemtuzumab ozogamicin (GO) in standard\u2010risk and high\u2010risk APL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a phase 2 trial of patients with newly diagnosed APL. Induction comprised ATRA 45 mg\/m<jats:sup>2<\/jats:sup> and ATO 0.15 mg\/kg daily. GO 6\u20139 mg\/m<jats:sup>2<\/jats:sup> was added for high\u2010risk patients and for standard\u2010risk patients who developed leukocytosis &gt;10\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L. Consolidation consisted of four courses of ATO\u2010ATRA, with GO for patients who had <jats:italic>PML::RARA<\/jats:italic> persistence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred forty\u2010six patients (median age, 53.0 years; range, 19.3\u201383.9 years) were treated, including 106 patients (72.6%) with standard\u2010risk APL and 40 (27.4%) with high\u2010risk APL. GO was administered to 68 standard\u2010risk patients (64.2%) for leukocytosis. The complete remission rate was 93.8% (95% confidence interval [CI], 92.2%\u201398.5%). Negative measurable residual disease status was achieved in 97.1% of patients who attained complete remission. At a median follow\u2010up of 61.8 months (95% CI, 4.7\u2013128.4 months), the 5\u2010year event\u2010free survival, disease\u2010free survival, and overall survival rates were 92.4% (95% CI, 87.9%\u201397.1%), 93.6% (95% CI, 89.5%\u201397.8%), and 93.1% (95% CI, 88.9%\u201397.7%), respectively. Induction mortality was 2.7%. The most common severe adverse events were elevated transaminases in 41.0% of patients and infection in 13.7%. There were no cases of veno\u2010occlusive disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of ATO\u2010ATRA and GO was curative in 94% of patients who had APL with a favorable safety profile (ClinicalTrials.gov identifier NCT01409161).<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35662","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T08:34:36Z","timestamp":1732523676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term follow\u2010up of a phase 2 study of all\u2010trans retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin in acute promyelocytic leukemia"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-3362","authenticated-orcid":false,"given":"Wei\u2010Ying","family":"Jen","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas 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