{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:15:17Z","timestamp":1791213317248,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prognosis of relapsed or refractory mature T\u2010 and natural killer (NK)\u2010cell lymphoma remains dismal. Novel agents are urgently needed to improve the outcomes for this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this phase 2, multicenter, open\u2010label, single\u2010arm study (NCT03776279), the authors report the efficacy and safety of liposomal mitoxantrone (Lipo\u2010MIT) monotherapy in patients with relapsed or refractory mature T\u2010 and NK\u2010cell lymphoma. Lipo\u2010MIT was administered intravenously at 20 mg\/m<jats:sup>2<\/jats:sup> once every 4 weeks. The primary end points were the objective response rate (ORR) determined by the independent review committee (IRC) and investigators. Secondary end points included duration of response (DoR), progression\u2010free survival (PFS), overall survival (OS), and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From April 26, 2018, to August 10, 2022, 108 eligible patients were enrolled and treated at 26 study centers in China. The ORRs were 41.7% (95% confidence interval [CI], 32.3\u201351.5%) per IRC and 46.3% (95% CI, 36.7%\u201356.2%) per investigators; 25 (23.1%) and 15 (13.9%) patients, respectively, achieved complete response. With a median follow\u2010up of 29.5 months, median PFS per IRC was 8.5 months (95% CI, 6.0\u201311.9); median OS was 23.3 months (95% CI, 12.0\u2013not evaluable); median DoR per IRC was not reached. The most frequent treatment\u2010emergent adverse events were decreased white blood cell count (75, 69.4%), decreased neutrophil count (73, 67.6%), and decreased platelet count (47, 43.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lipo\u2010MIT monotherapy showed robust and durable antitumor activity with a manageable safety profile, representing a new therapeutic option in relapsed or refractory mature T\u2010 and NK\u2010cell lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35672","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T01:19:27Z","timestamp":1735867167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Liposomal mitoxantrone monotherapy in patients with relapsed or refractory mature T\u2010cell and natural killer\u2010cell neoplasms: A phase 2, multicenter, open\u2010label, single\u2010arm 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