{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:32:37Z","timestamp":1788028357472,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Black race is associated with poorer prognosis in hormone receptor (HR)\u2013positive, HER2\u2010negative early breast cancer (EBC). The impact of race\/ethnicity on the risk distribution and prognostic information provided by the 70\u2010gene MammaPrint assay was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with HR\u2010positive EBC with tumors up to 5 cm in size and zero to three involved lymph nodes, who were diagnosed between 2009 and 2018, and who had an available MammaPrint result were identified in the National Cancer Data Base (NCDB). <jats:italic>t<\/jats:italic>\u2010tests and \u03c7<jats:sup>2<\/jats:sup> tests were used to compare patient characteristics, whereas log\u2010rank tests assessed differences in overall survival (OS) between racial\/ethnic subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 6137 women included, 82.8% (<jats:italic>n<\/jats:italic>\u00a0=\u00a05084) were non\u2010Hispanic White, 8.9% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0545) were non\u2010Hispanic Black (NHB), 4.8% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0292) were Hispanic, and the remainder were other\/unknown (<jats:italic>n<\/jats:italic>\u00a0=\u00a0216). Of these women, 58.4% (<jats:italic>n<\/jats:italic>\u00a0=\u00a03587) were MammaPrint low risk and 41.6% (<jats:italic>n<\/jats:italic>\u00a0=\u00a02550) were MammaPrint high risk. NHB and Hispanic women were more likely to have a high\u2010risk MammaPrint result (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) than other racial\/ethnic subgroups. Five\u2010year OS was worse for the MammaPrint high\u2010risk versus low\u2010risk group (92.6% vs. 96.6%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). There were no significant differences in OS on the basis of race\/ethnicity in the MammaPrint low\u2010risk (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.34) or high\u2010risk (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.79) subgroups. However, Black race did not affect mortality in the overall population (hazard ratio, 1.15; 95% confidence interval, 0.84\u20131.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NHB and Hispanic women were more likely to have high\u2010risk MammaPrint results in this NCDB cohort. Although there were no differences in survival by race\/ethnicity in the MammaPrint low\u2010 and high\u2010risk groups, these findings are limited by the lack of association between race\/ethnicity and mortality in the overall population when adjusting for other clinicopathologic prognostic covariates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35771","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:55:02Z","timestamp":1741733702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of race\/ethnicity on MammaPrint genomic assay risk and prognosis in early breast cancer: A National Cancer Data Base analysis"],"prefix":"10.1002","volume":"131","author":[{"given":"Rima B.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology Department of Medicine Tisch Cancer Institute Icahn School of Medicine at Mount Sinai  New York 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Hematology and Medical Oncology Department of Medicine Tisch Cancer Institute Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Tiersten","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Department of Medicine Tisch Cancer Institute Icahn School of Medicine at Mount Sinai  New York New York 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