{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:07:08Z","timestamp":1792523228465,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inotuzumab ozogamicin (IO) has helped to change the treatment paradigm in B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) but real\u2010world data are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The INO\u2010CD22 study is a multicenter retrospective cohort study of adult patients with relapsed\/refractory B\u2010ALL treated with IO in 24 Italian centers from 2014 to 2019, with the aim of assessing the response, survival, and toxicity of IO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data for 73 eligible patients were obtained: the median age at the start of IO treatment was 52.7 years (I\u2013III quartiles, 51.9\u201353.5 years), the median number of previous lines was three (I\u2013III quartiles, two to four), and prior exposure to induction standard chemotherapy and blinatumomab occurred in 85% and 57.5% of cases, respectively. IO was administered following the label schedule. A 74.0% overall response rate was achieved, with a 69.8% complete remission rate and a 4.1% complete remission with incomplete hematologic reconstitution rate. The median duration of response was 4.4 months (I\u2013III quartiles, 2.3\u201311.2 months). With a median follow\u2010up of 37.2 months, the median overall survival (OS) was 7.9 months (95% CI, 6.08\u201312.42 months) with a 3\u2010 and 5\u2010year OS of 21.2% (95% CI, 11.9%\u201332.3%) and 5.3% (95% CI, 9.6%\u201329.8%), respectively. Overall, 37% of patients were able to proceed to allogeneic hematopoietic stem cell transplantation. Eight patients (11.0%) experienced veno\u2010occlusive disease\/sinusoidal obstruction syndrome; the most frequent grade \u22653 nonhematologic adverse events were liver toxicities and pneumonia (two grade 4 and one grade 5, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the limitations of retrospective studies, the INO\u2010CD22 study highlights the favorable safety profile and clinical activity of IO within a real\u2010world context.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35820","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T13:33:40Z","timestamp":1742736820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["INO\u2010CD22: A multicenter, real\u2010world study of inotuzumab ozogamicin safety and effectiveness in adult patients with relapsed\/refractory acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-8333","authenticated-orcid":false,"given":"Cristina","family":"Papayannidis","sequence":"first","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2013Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Petracci","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics and Clinical Trials IRCCS Istituto Romagnolo per lo Studio dei Tumori \u201cDino Amadori\u201d  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Zappasodi","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo University of Pavia  Pavia 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