{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:47:31Z","timestamp":1775501251676,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic impact of cohesin mutations in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In patients with AML and MDS who underwent next\u2010generation sequencing at the authors' center during 2017\u20132023, the authors assessed the landscape of cohesin mutations and the impact of co\u2010occurring mutations on overall survival (OS) and compared outcomes between patients with cohesin mutations and those with wild\u2010type (WT) cohesin genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 83 patients, 36 with cohesin mutations (<jats:italic>STAG2<\/jats:italic>, <jats:italic>n<\/jats:italic>\u00a0=\u00a028; <jats:italic>SMC1A<\/jats:italic>, <jats:italic>n<\/jats:italic>\u00a0=\u00a07; <jats:italic>SMC3<\/jats:italic>, <jats:italic>n<\/jats:italic>\u00a0=\u00a03; co\u2010expression of cohesin mutations, <jats:italic>n<\/jats:italic>\u00a0=\u00a02) and 47 with WT cohesin genes. Of the 36 patients with cohesin mutations, 17 (47%) had AML (six de novo and 11 secondary), and 19 (53%) had MDS. Patients who had <jats:italic>STAG2<\/jats:italic> mutations had better median OS than patients who had only <jats:italic>SMC1A<\/jats:italic> and <jats:italic>SMC3<\/jats:italic> mutations (26 vs. 10 months; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.043). <jats:italic>SRSF2<\/jats:italic> mutation was the most frequent co\u2010occurring mutation (<jats:italic>n<\/jats:italic>\u00a0=\u00a012; 33%) and was associated with worse median OS than WT <jats:italic>SRSF2<\/jats:italic> (13 vs. 43 months; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.016). Seven patients (19%) with cohesin mutations underwent hematopoietic transplantation; their median OS was 70 months. Compared with the WT cohesin group, patients who had cohesin mutations were more likely to have adverse\u2010risk AML (82% vs. 53%). The median OS was similar among patients with adverse\u2010risk AML in the cohesin\u2010mutation and WT cohesin groups (10 vs. 14 months, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current study provides insight into the prognostic impact of cohesin mutations and co\u2010occurring mutations in patients with myeloid malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35846","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:18:44Z","timestamp":1744478324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics and clinical outcomes of patients with myeloid malignancies and cohesin mutations"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0644-9898","authenticated-orcid":false,"given":"Maria R.","family":"Khouri","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cancer Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie K.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Gillis\u2010Smith","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd M.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Department of Pathology UMass Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poorva","family":"Bindal","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8221-3605","authenticated-orcid":false,"given":"Muthalagu","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts USA"},{"name":"Perlmutter Cancer Center New York University Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Cerny","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine UMass Memorial Medical Center UMass Chan Medical School  Worcester Massachusetts 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