{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:36:04Z","timestamp":1788028564950,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the phase 3 EMPOWER\u2010Lung 1 study, first\u2010line cemiplimab monotherapy provided significant survival benefit versus chemotherapy in patients with advanced non\u2013small cell lung cancer (NSCLC) with programmed cell death\u2010ligand 1 (PD\u2010L1) \u226550%. This exploratory subgroup analysis investigated the clinical outcomes of cemiplimab treatment in patients with advanced NSCLC with brain metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with advanced NSCLC were randomized (1:1) to cemiplimab 350 mg every 3 weeks or four cycles of platinum doublet chemotherapy (NCT03088540). Patients with symptomatic radiotherapy\u2010treated brain metastases were eligible to enroll. Of the 565 patients with confirmed PD\u2010L1 expression \u226550%, 69 (12%) had brain metastases at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with brain metastases who received cemiplimab had a median overall survival (OS) of 52.4 months compared with 20.7 months for those who received chemotherapy (hazard ratio [HR], 0.40; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0031) and a median progression\u2010free survival (PFS) of 12.5 versus 5.3 months (HR, 0.33; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0002), respectively. Patients without brain metastases had a median OS of 24.3 months with cemiplimab versus 12.5 months with chemotherapy (HR, 0.63; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001); their median PFS was 6.5 months versus 5.2 months (HR, 0.55; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), respectively. Cemiplimab was associated with a significant improvement in global health status\/quality of life in all patients, including those with brain metastases. The cemiplimab safety profile was generally similar in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with advanced NSCLC with PD\u2010L1 \u226550%, first\u2010line cemiplimab monotherapy improved survival and patient\u2010reported outcomes over chemotherapy for those who received prior radiotherapy for symptomatic brain metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35864","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T12:14:03Z","timestamp":1746447243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cemiplimab monotherapy as first\u2010line treatment of patients with brain metastases from advanced non\u2013small cell lung cancer with programmed cell death\u2010ligand 1 \u226550%"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-7390","authenticated-orcid":false,"given":"Saadettin","family":"Kilickap","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Istinye University Faculty of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00d6zg\u00fcro\u011flu","sequence":"additional","affiliation":[{"name":"Cerrahpa\u015fa Medical Faculty Istanbul University\u2010Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ba\u015fkent University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-9993","authenticated-orcid":false,"given":"Mahmut","family":"G\u00fcm\u00fc\u015f","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology School of Medicine Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"Department of Oncology and Medical Radiology Dnipropetrovsk Medical Academy  Dnipro Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Gogishvili","sequence":"additional","affiliation":[{"name":"High Technology Medical Centre University Clinic, Ltd  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haci M.","family":"Turk","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Bezmialem Vakif University, Medical Faculty  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7584-3868","authenticated-orcid":false,"given":"Irfan","family":"Cicin","sequence":"additional","affiliation":[{"name":"Istinya University Faculty of Medicine, Florya Medical Park Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Bentsion","sequence":"additional","affiliation":[{"name":"Radiotherapy Department Sverdlovsk Regional Oncology Centre  Sverdlovsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Gladkov","sequence":"additional","affiliation":[{"name":"LLC, \u201cEVIMED\u201d  Chelyabinsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virote","family":"Sriuranpong","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Medicine Faculty of Medicine Chulalongkorn University and the King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben G. 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