{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:22Z","timestamp":1786977502352,"version":"build-2736575974"},"reference-count":216,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30\u00a0CA016672"],"award-info":[{"award-number":["P30\u00a0CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The past decade has witnessed remarkable advances in deciphering the pathophysiology of acute lymphoblastic leukemia (ALL) and in developing novel targeted therapies. Basic research and genomic mapping have identified new prognostic biomarkers, targets, and ALL subtypes (e.g., Philadelphia\u2010like ALL). The ongoing therapeutic revolution in ALL is driven by the addition to the treatment arsenal of therapies that target the\n                    <jats:italic>ABL<\/jats:italic>\n                    fusions, like the BCR::ABL1 tyrosine kinase inhibitors, as well as novel agents that target CD19 and CD22: the CD22 antibody\u2013drug conjugate inotuzumab ozogamicin, the bispecific CD3\/CD19 T\u2010cell engager antibody blinatumomab, and CD19 chimeric antigen receptor T\u2010cell therapies. These combinations have improved the long\u2010term survival rates in B\u2010cell ALL to 70%, and in Philadelphia chromosome\u2010positive ALL to 80%\u201390%. The desired goals are to achieve cure rates comparable to those in pediatric ALL and to reduce or eliminate the need for prolonged intensive\/maintenance chemotherapy and associated toxicities.\n                  <\/jats:p>","DOI":"10.1002\/cncr.35872","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T12:37:59Z","timestamp":1746448679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The evolving therapeutic revolution in adult acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-3307","authenticated-orcid":false,"given":"Hagop","family":"Kantarjian","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Litzow","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina M.","family":"Luger","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-8333","authenticated-orcid":false,"given":"Cristina","family":"Papayannidis","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-6024","authenticated-orcid":false,"given":"Josep\u2010Maria","family":"Ribera","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department and Stem Cell Transplantation Unit Catalan Institute of Oncology  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-2738","authenticated-orcid":false,"given":"Nicholas J.","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8044-4960","authenticated-orcid":false,"given":"Helen T.","family":"Chifotides","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-6119","authenticated-orcid":false,"given":"Elias","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.59.1636"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001277\u20103"},{"key":"e_1_2_18_4_1","volume-title":"SEER Cancer Stat Facts: Acute Lymphocytic Leukemia","author":"National Cancer Institute; Surveillance, Epidemiology, and End Results (SEER) Program","year":"2024"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26156"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation\u20102018.1.137"},{"key":"e_1_2_18_7_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132018","author":"Howlader N","year":"2021"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20104642(18)30066\u2010x"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2000.18.3.547"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001409\u20105"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(23)00073\u2010X"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201007\u2010379016"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.26.9456"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/jop.18.00271"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/2278\u2010330x.187591"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.08.023"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29875"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/jgo.17.00014"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)33326\u20103"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010186942"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2018.07.013"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288\u2010020\u201001345\u20101"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1255555"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1513"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2016.08.013"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2019.106235"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/go.22.00288"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17268"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(23)00318\u20102"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009754"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.09.010"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201011\u2010749507"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.710163"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281820"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.118588"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29646"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016001495"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26816"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27355"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509277"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609783"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201008\u2010596403"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.2398"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102007\u201009\u2010112920"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2016272"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.5868"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(22)00319\u20102"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.4783"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.24.00272"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214171"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312948"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010024\u201002414\u20104"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2023.101485"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.06.007"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.1915"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201007\u2010726588"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010024\u201002368\u20107"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201005812\u20103"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201005\u2010018192"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404824"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0001"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001620\u20102"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020794"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30011\u20101"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35505"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001552\u20107"},{"issue":"1","key":"e_1_2_18_67_1","article-title":"Blinatumomab added to prephase and consolidation therapy in adult B\u2010ALL: a comparison of the consecutive HOVON\u2010100 and H\u2010146 studies [abstract]","volume":"8","author":"Van Baalen E","year":"2024","journal-title":"Hemasphere"},{"key":"e_1_2_18_68_1","doi-asserted-by":"crossref","unstructured":"KantarjianHM WaltersRS SmithTL et\u00a0al.Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia.1988;72(5):1784\u20101789. doi:10.1182\/blood.v72.5.1784.1784","DOI":"10.1182\/blood.V72.5.1784.bloodjournal7251784"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v86.6.2091.bloodjournal8662091"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26622"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2009.05.002"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201011\u20104666"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900386"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32606"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006926"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605085"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102019\u2010122990"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.00303"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004427"},{"key":"e_1_2_18_80_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.283342"},{"key":"e_1_2_18_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.09.608"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012231"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(08)70314\u20100"},{"key":"e_1_2_18_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3041"},{"key":"e_1_2_18_85_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201008\u2010661702"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26144"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020678"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10725"},{"key":"e_1_2_18_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010019\u20100647\u20107"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024936"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201010\u2010743765"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2532"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643\u20103230.Bcd\u201022\u20100154"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004580"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021501"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102019\u2010121977"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.03.299"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(08)70339\u20105"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2803"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403088"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001244"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1200\/po.22.00707"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.69.0073"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.117424"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.136366"},{"key":"e_1_2_18_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25338"},{"key":"e_1_2_18_107_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0580"},{"key":"e_1_2_18_108_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201008\u2010798322"},{"key":"e_1_2_18_109_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022330"},{"key":"e_1_2_18_110_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022922"},{"key":"e_1_2_18_111_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280638"},{"key":"e_1_2_18_112_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007311"},{"key":"e_1_2_18_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26949"},{"key":"e_1_2_18_114_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007378"},{"key":"e_1_2_18_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2023.12.007"},{"key":"e_1_2_18_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2023.12.013"},{"key":"e_1_2_18_117_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004234"},{"key":"e_1_2_18_118_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.24.00108"},{"key":"e_1_2_18_119_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201009\u2010529008"},{"key":"e_1_2_18_120_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201002\u2010627935"},{"key":"e_1_2_18_121_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023502"},{"key":"e_1_2_18_122_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201002\u2010700153"},{"key":"e_1_2_18_123_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201099\u2010114552"},{"key":"e_1_2_18_124_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.260935"},{"key":"e_1_2_18_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(18)30176\u20105"},{"key":"e_1_2_18_126_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004821"},{"key":"e_1_2_18_127_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007764"},{"key":"e_1_2_18_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.67"},{"key":"e_1_2_18_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30231"},{"key":"e_1_2_18_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2018.02.010"},{"key":"e_1_2_18_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010023\u201002497\u2010y"},{"key":"e_1_2_18_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.12.022"},{"key":"e_1_2_18_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.08.101"},{"key":"e_1_2_18_134_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.01075"},{"key":"e_1_2_18_135_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008216"},{"key":"e_1_2_18_136_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102024\u2010207892"},{"key":"e_1_2_18_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27463"},{"key":"e_1_2_18_138_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010186139"},{"key":"e_1_2_18_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27227"},{"key":"e_1_2_18_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26238"},{"key":"e_1_2_18_141_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102024\u2010193442"},{"key":"e_1_2_18_142_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201003\u2010707562"},{"key":"e_1_2_18_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33529"},{"key":"e_1_2_18_144_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016194"},{"key":"e_1_2_18_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35773"},{"key":"e_1_2_18_146_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201001\u2010130237"},{"key":"e_1_2_18_147_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.18.6916"},{"key":"e_1_2_18_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.229"},{"key":"e_1_2_18_149_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.5305"},{"key":"e_1_2_18_150_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201010\u2010881961"},{"key":"e_1_2_18_151_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002439"},{"key":"e_1_2_18_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24419"},{"key":"e_1_2_18_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28930"},{"key":"e_1_2_18_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(20)30144\u20107"},{"key":"e_1_2_18_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33655"},{"key":"e_1_2_18_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(15)01317\u20103"},{"key":"e_1_2_18_157_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011994"},{"key":"e_1_2_18_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(22)00285\u2010x"},{"key":"e_1_2_18_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27576"},{"key":"e_1_2_18_160_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010159397"},{"key":"e_1_2_18_161_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010174973"},{"key":"e_1_2_18_162_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001597\u20108"},{"key":"e_1_2_18_163_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.286427"},{"key":"e_1_2_18_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2015.11.012"},{"key":"e_1_2_18_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23819"},{"key":"e_1_2_18_166_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.3981.3981"},{"key":"e_1_2_18_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899\u2010018\u20100440\u20103"},{"key":"e_1_2_18_168_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.01766"},{"key":"e_1_2_18_169_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.00546"},{"key":"e_1_2_18_170_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010166035"},{"key":"e_1_2_18_171_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010180472"},{"key":"e_1_2_18_172_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.7006"},{"key":"e_1_2_18_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32139"},{"key":"e_1_2_18_174_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014405"},{"key":"e_1_2_18_175_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102003\u201012\u20104428"},{"key":"e_1_2_18_176_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102021\u2010152355"},{"key":"e_1_2_18_177_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010303"},{"key":"e_1_2_18_178_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201011\u2010056754"},{"key":"e_1_2_18_179_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.Cd\u201020\u20101465"},{"key":"e_1_2_18_180_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279851"},{"key":"e_1_2_18_181_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.283848"},{"key":"e_1_2_18_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27094"},{"key":"e_1_2_18_183_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014498"},{"key":"e_1_2_18_184_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201001\u2010761320"},{"key":"e_1_2_18_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32116"},{"key":"e_1_2_18_186_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102024\u2010205662"},{"key":"e_1_2_18_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26634"},{"key":"e_1_2_18_188_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03585"},{"key":"e_1_2_18_189_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201012\u2010399287"},{"key":"e_1_2_18_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29901"},{"key":"e_1_2_18_191_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008280"},{"key":"e_1_2_18_192_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201000856\u20108"},{"key":"e_1_2_18_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(11)70386\u20102"},{"key":"e_1_2_18_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28136"},{"key":"e_1_2_18_195_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2380"},{"key":"e_1_2_18_196_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001444\u20102"},{"key":"e_1_2_18_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2152\u20102650(24)01140\u20106"},{"key":"e_1_2_18_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2023.12.016"},{"key":"e_1_2_18_199_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009462"},{"key":"e_1_2_18_200_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_2_18_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010025\u201002532\u20107"},{"key":"e_1_2_18_202_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010182531"},{"key":"e_1_2_18_203_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6504"},{"key":"e_1_2_18_204_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2406526"},{"key":"e_1_2_18_205_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102024\u2010194508"},{"key":"e_1_2_18_206_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.Hs9.0000843344.19780.98"},{"key":"e_1_2_18_207_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.22.00642"},{"key":"e_1_2_18_208_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6531"},{"key":"e_1_2_18_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.09.027"},{"key":"e_1_2_18_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02664"},{"key":"e_1_2_18_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(23)00517\u2010X"},{"key":"e_1_2_18_212_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020621"},{"key":"e_1_2_18_213_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001436\u20100"},{"key":"e_1_2_18_214_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010187252"},{"key":"e_1_2_18_215_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010186225"},{"key":"e_1_2_18_216_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013733"},{"key":"e_1_2_18_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(21)00238\u20106"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:16:27Z","timestamp":1760296587000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":216,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,5,15]]}},"alternative-id":["10.1002\/cncr.35872"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35872","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,5]]},"assertion":[{"value":"2024-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35872"}}