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Integration of molecular testing in endometrial cancer now allows for more accurate risk stratification and personalized treatment recommendations for patients, with PORTEC\u20104a investigating outcomes after treatment de\u2010escalation based on molecular subgroup. In several clinical trials, mismatch repair\u2010deficiency (MMR\u2010d) status has been proven to be a strong predictor for response to immunotherapy in the advanced\/metastatic setting, and the role of immunotherapy in early\u2010stage endometrial cancer is now being investigated. For patients with locally advanced cervical cancer, results from INTERLACE demonstrate that induction chemotherapy is now a viable treatment option, and KEYNOTE A\u201018 shows promise for the addition of concurrent and maintenance pembrolizumab to chemoradiation. Meanwhile, EMBRACE 1 and 2 have demonstrated the benefits of high\u2010quality image guided brachytherapy, providing patients with locally advanced cervical cancer excellent control with improved toxicity. For patients with vulvar cancer, GOG279 demonstrated that addition of multi\u2010agent chemotherapy with intensity modulated radiation therapy resulted in high rates of complete pathologic response, and GROINS\u2010V III is currently investigating the role of chemotherapy and nodal radiation for patients with macrometastases on sentinel lymph node biopsy. This work summarizes the findings of recent landmark trials in endometrial, cervical, and vulvar cancer and their implications for the radiation oncologist.<\/jats:p>","DOI":"10.1002\/cncr.35888","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T10:11:06Z","timestamp":1746180666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recent advances in gynecologic radiation oncology"],"prefix":"10.1002","volume":"131","author":[{"given":"Christina C.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-4499","authenticated-orcid":false,"given":"Diandra N.","family":"Ayala\u2010Peacock","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Duke University 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