{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:54:06Z","timestamp":1760316846230,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allogeneic stem cell transplantation (allo\u2010SCT) has curative potential and was previously considered by several experts superior to autologous stem cell transplantation (auto\u2010SCT) for patients with multiple myeloma relapsing after first\u2010line auto\u2010SCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors conducted a comprehensive literature review of English\u2010language studies published from 1995 to October 2024. Five studies comparing allo\u2010SCT with second auto\u2010SCT following first line auto\u2010SCT in multiple myeloma were included. Two additional studies comparing patients with or without a suitable allo\u2010SCT donor after relapse were analyzed separately. Individual data from 815 patients were obtained from two large databases: the Japan Society for Hematopoietic Stem Cell Transplantation and the Center for International Blood &amp; Marrow Transplant Research (CIBMTR). Data from five smaller studies (three comparing allo\u2010vs. auto\u2010SCT and two comparing donor vs. no\u2010donor groups) presented via Kaplan\u2013Meier curves were digitized using the Shiny app. Meta\u2010analyses were performed using R 4.3.3. Kaplan\u2013Meier and log\u2010rank tests for overall survival (OS) and progression\u2010free survival (PFS) were conducted in SPSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individual patient data analysis showed significantly longer OS in the auto\u2010SCT group. This benefit was consistent in the three smaller studies. PFS was also superior for auto\u2010SCT in the CIBMTR data set and the pooled smaller studies. In the two\u2010donor vs. no\u2010donor studies, the donor group showed better PFS, with OS also improved when data were combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Allo\u2010SCT after relapse from first line auto\u2010SCT resulted in inferior OS and PFS compared to a second auto\u2010SCT. These findings indicate that allo\u2010SCT should no longer be recommended in patients with multiple myeloma relapsing after first line auto\u2010SCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35896","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T13:09:13Z","timestamp":1746623353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Allogeneic versus autologous stem cell transplantation after relapsing following first line autologous transplantation for multiple myeloma: A systematic review"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-8726","authenticated-orcid":false,"given":"Heinz","family":"Ludwig","sequence":"first","affiliation":[{"name":"Wilhelminen Cancer Research Institute  Vienna 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