{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:04:33Z","timestamp":1792533873047,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006386","name":"Adenoid Cystic Carcinoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenoid cystic carcinoma (ACC) frequently has pulmonary metastasis (PM). Given limited systemic therapy options, these metastases are often treated with pulmonary metastasis\u2013directed local therapy (PM\u2010LT), although with unknown impact on overall survival (OS). This single institution, retrospective cohort study investigated the survival outcomes of PM\u2010LT versus no PM\u2010LT in ACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ACC patients with at least one PM (\u22655 mm) were included. PM\u2010LT was metastasectomy or radiotherapy. Clinicopathologic characteristics were compared between patients with and without PM\u2010LT. Primary end point was OS from PM diagnosis, with landmark analysis at 6 months, 1 year, 2 years, and 3 years after metastasis diagnosis, with Cox proportional hazards model multivariate analysis and propensity score matching analysis. Subgroup analysis by ACC histology (solid\/nonsolid) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 219 included ACC, 119 (54%) had no PM\u2010LT and 100 (46%) did. PM\u2010LT patients had more nonsolid histology (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0008), oligometastases (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), exclusively PM (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02), and longer time to metastasis from diagnosis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). On univariate analysis, PM\u2010LT by 6 months, 1 year, and 2 years, but not by 3 years, increased OS. On multivariate analysis, PM\u2010LT by 6 months (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.12), 1 year (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.08), or 3 years (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.08) did not significantly increase OS, but PM\u2010LT by 2\u2010years had a borderline statistically significant association (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.045). Of the 104 nonsolid ACC, 50 underwent PM\u2010LT and 54 did not. On univariate and multivariate analysis, PM\u2010LT did not increase OS at any time point for nonsolid ACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the largest study of survival outcomes of PM\u2010LT in metastatic ACC. Findings suggest PM\u2010LT does not increase OS in unselected ACC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35901","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T07:10:39Z","timestamp":1747379439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Survival outcomes of pulmonary metastasis\u2010directed local therapy in adenoid cystic carcinoma"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-8438","authenticated-orcid":false,"given":"Camilla O.","family":"Hoff","sequence":"first","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"School of Medicine University of Sao Paulo  Sao Paulo 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