{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:13:25Z","timestamp":1789881205957,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Over the past decade, remarkable improvements have been seen in oncology. The survival rate for breast cancer has more than doubled since 1975. Even diseases previously known for having poor prognoses, such as lung cancer, saw an improvement in survival over this period. To that end, the aim of this commentary is to evaluate how patients with soft tissue sarcoma (STS) fared during this period. By analyzing data from 21,948 patients with STS (excluding gastrointestinal stromal tumor [GIST]) from the Surveillance, Epidemiology, and End Results 9 registries, this study determined that the median survival has remained stagnant from 1999 to 2019 (66\u201368 months); even when stratified by localized or distant disease, no significant difference was seen. However, when looking specifically at GIST (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03716), there was a steady improvement in survival during the same period, with the median survival increasing from 105 months in 1999\u20132004 to 122 months in 2005\u20132011. These survival improvements were seen in both localized and distant settings. Multiple factors can be attributed to the stagnation of STS in comparison with other cancers, including the lack of understanding of its biological mechanisms, difficulties in conducting research in rare diseases, and lack of commercial interest in positioning drugs in this disease. The contrasting progress in GIST highlights that this reality can be changed; by understanding the biological drivers, actionable targets can be found and novel drugs can be positioned to improve survival.\n                  <\/jats:p>","DOI":"10.1002\/cncr.35906","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T07:44:45Z","timestamp":1747813485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Twenty\u2010five years without progress: The enduring challenge of soft tissue sarcomas"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-0371","authenticated-orcid":false,"given":"Nicole J.","family":"Hardy","sequence":"first","affiliation":[{"name":"University of Connecticut School of Medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaoula Ben Haj","family":"Frej","sequence":"additional","affiliation":[{"name":"University of Connecticut School of Medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Nkansah","sequence":"additional","affiliation":[{"name":"University of Connecticut School of Medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Olino","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Epidemiology Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Trent","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center University of Miami Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippos","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7836264"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.25881"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.22.00012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ortho.IJOrtho_220_17"},{"key":"e_1_2_10_8_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program SEER*Stat Database: Incidence \u2010 SEER Research Data 8 Registries Nov 2023 Sub (1975\u20102021) \u2010 Linked To County Attributes \u2010 Time Dependent (1990\u20102022) Income\/Rurality 1969\u20102022 Counties National Cancer Institute DCCPS Surveillance Research Program. 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