{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:59Z","timestamp":1790717099926,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000321","name":"World Cancer Research Fund","doi-asserted-by":"publisher","award":["IIG_2019_1978"],"award-info":[{"award-number":["IIG_2019_1978"]}],"id":[{"id":"10.13039\/501100000321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adiposity, measured by body mass index (BMI), is a known risk factor for postmenopausal breast cancer. However, whether the association of BMI with breast cancer risk differs among women with and without cardiovascular diseases (CVDs) or type 2 diabetes (T2D) is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study used individual participant data from the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank (UKB) that included 168,547 postmenopausal women who were free of cancer, T2D, and CVD at recruitment. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with multivariable\u2010adjusted Cox regression for associations between BMI and incident breast cancer by T2D and CVD status. Incidence rates per 1000 person\u2010years and rate differences between observed and expected joint associations of adiposity and CVD or T2D for breast cancer were estimated. Study\u2010specific estimates were meta\u2010analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median follow\u2010up of 10.7 years in EPIC and 10.9 years in UKB, 6793 postmenopausal women developed breast cancer. In the meta\u2010analysis of both cohorts, BMI (per 1\u2010SD increment, 5 kg\/m<jats:sup>2<\/jats:sup>) was more strongly associated with breast cancer risk in women with CVD (HR, 1.31; 95% CI, 1.16 to 1.47) than in women without CVD (HR, 1.13; 95% CI, 1.11 to 1.16) (<jats:italic>p<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a0.02). T2D did not modify breast cancer risk (<jats:italic>p<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a0.33). The meta\u2010analyzed joint association of overweight or obesity (BMI, \u226525 kg\/m<jats:sup>2<\/jats:sup>) and CVD led to 1.53 (95% CI, 0.35 to 2.71) more cases of breast cancer per 1000 person\u2010years than expected but no such joint association was observed with T2D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adiposity\u2010associated risk of breast cancer was substantially higher among women with CVD as compared to those without CVD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35911","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T03:03:11Z","timestamp":1751857391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Body mass index and breast cancer risk among postmenopausal women with and without cardiometabolic diseases: Findings from two prospective cohort studies in Europe"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5488-9317","authenticated-orcid":false,"given":"Emma","family":"Fontvieille","sequence":"first","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer (IARC\u2010WHO)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jansana","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer (IARC\u2010WHO)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Peruchet\u2010Noray","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer (IARC\u2010WHO)  Lyon France"},{"name":"Department of Clinical Sciences Faculty of Medicine University of Barcelona  Barcelona 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