{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:18:52Z","timestamp":1785799132400,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The disproportionate burden of obesity among Black women may contribute to disparities in breast cancer survival; yet, associations of body mass index (BMI), a proxy for total adiposity, are inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To examine racial\/ethnic differences in body composition and evaluate associations with breast cancer\u2013specific and all\u2010cause mortality, this study identified 3898 women 18 to &lt;90 years old, diagnosed in 2005\u20132019 with stage II\u2010III breast cancer at Kaiser Permanente Northern California. The authors measured subcutaneous, visceral, and intermuscular adipose tissue area from computed tomography scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body composition differed by race: compared to other race\/ethnicity groups, Black women had higher skeletal muscle and subcutaneous adipose, but lower visceral adipose tissues, whereas Asian\/Pacific Islander women had lower intermuscular and subcutaneous adipose tissue. BMI was not significantly associated with mortality in any group. Among Black women, higher subcutaneous adipose tissue was associated with breast cancer\u2013specific mortality (hazard ratio [HR], 1.24; 95% confidence interval [CI], 1.02\u20131.52) and all adipose tissue measures were associated with increased all\u2010cause mortality (intermuscular HR, 1.26; 95% CI, 1.09\u20131.46; subcutaneous HR, 1.25; 95% CI, 1.05\u20131.48; and visceral HR, 1.32; 95% CI, 1.03\u20131.68, respectively). By contrast, only increased intermuscular adipose tissue was associated with all\u2010cause mortality among White women (HR, 1.08; 95% CI, 1.00\u20131.16), with null associations for Hispanic and Asian\/Pacific Islander women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BMI obscures variation in body composition, particularly for Black women, who have more subcutaneous adipose and skeletal muscle but less visceral adipose tissue at higher BMIs. These findings from routine imaging highlight opportunities for tailored lifestyle interventions to improve survivorship and mitigate disparities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35926","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T14:04:58Z","timestamp":1749218698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Racial and ethnic variation in body composition and prognosis of nonmetastatic breast cancer"],"prefix":"10.1002","volume":"131","author":[{"given":"Ijeamaka A.","family":"Fumagalli","sequence":"first","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Pleasanton California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-0313","authenticated-orcid":false,"given":"Erica T.","family":"Warner","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-9121","authenticated-orcid":false,"given":"Adana A. 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