{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:41:27Z","timestamp":1774374087759,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>There is a paucity of data on treatment outcomes following stereotactic radiosurgery (SRS) for brain metastases from sarcoma primaries.<\/jats:p><\/jats:sec>Methods<\/jats:title>The International Radiosurgery Research Foundation member\u2010sites were queried for patients with brain metastases from sarcoma primaries treated with SRS. Overall survival (OS) and local control (LC) were calculated via Kaplan\u2013Meier analysis. Univariate analyses examined prognostic factors associated with LC and OS via log\u2010rank t<\/jats:italic>\u2010tests and multivariate analyses (MVA) via Cox proportional hazards model.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 146 patients with 309 brain metastases were identified. Two\u2010hundred and thirty lesions were treated with single\u2010fraction SRS with a median dose of 20 Gy (15\u201324 Gy). Ninety\u2010five patients had extracranial metastases, including 75 oligometastatic patients. One\u2010 and 2\u2010year OS and LC rates were 47.7% and 37.3%, and 78.3% and 62.2%, respectively. On univariate analyses, superior 1\u2010year OS was noted among leiomyosarcomas (69.7% vs. 42.6%; p<\/jats:italic>\u00a0=\u00a0.02) with poorer outcomes among pleomorphic histologies (10.5% vs. 50.7%; p<\/jats:italic>\u00a0=\u00a0.002). Pleomorphic histologies were associated with poorer OS on MVA (hazard ratio [HR],\u00a03.13; p<\/jats:italic>\u00a0=\u00a0.006). On MVA, LC was inferior among patients of age \u226545 years (HR,\u00a03.78; p<\/jats:italic>\u00a0<\u00a0.001) and superior among leiomyosarcomas (HR,\u00a00.31; p<\/jats:italic>\u00a0=\u00a0.03). OS was prognosticated based on adverse factors (ie, nonleiomyosarcoma histology and progressive extracranial metastases). Two\u2010year OS for patients with and without adverse features were 78.6% and 31.5%, respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>LC outcomes were driven by histology and age with superior LC among leiomyosarcomas and patients of age <45 years. OS was driven by nonleiomyosarcoma histology and the presence of progressive extracranial disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35931","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T12:49:43Z","timestamp":1750510183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical outcomes following stereotactic radiosurgery for brain metastases from sarcoma primaries: An international multicenter analysis"],"prefix":"10.1002","volume":"131","author":[{"given":"Raj","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Roubil","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massey Comprehensive Cancer Center Virginia Commonwealth University Health System Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Bowden","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Department of Surgery Universit\u00e9 de Sherbrooke Centre de recherche du CHUS Sherbrooke Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Carrier","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Department of Surgery Universit\u00e9 de Sherbrooke Centre de recherche du CHUS Sherbrooke Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Shepard","sequence":"additional","affiliation":[{"name":"Department of 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