{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:26:46Z","timestamp":1764433606126,"version":"3.46.0"},"reference-count":81,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this review on the status of tolerability in pediatric oncology, the authors address the relevance and meaning of this important concept and offer a definition to represent treatment tolerability experiences of pediatric, adolescent, and young adult oncology patients. The authors acknowledge the incomplete progress of tolerability research in pediatric oncology clinical trials while describing the recent advances in validating relevant measures and embedding these in pediatric oncology clinical trials to document the symptom burden of specific cancer treatments. They advocate for the consistent use of three voices\u2014patient, caregiver, and clinician\u2014in pediatric oncology to achieve accurate and comprehensive estimates of treatment tolerability while recognizing that a primary voice may be necessary to match the main aim or goal of the proposed research. Future steps include establishing the validity of tolerability measures and methods in patients younger than 7 years and a careful examination of tolerability issues into survivorship.<\/jats:p>","DOI":"10.1002\/cncr.35947","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:46:18Z","timestamp":1761144378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Defining and measuring tolerability in pediatric, adolescent, and young adult oncology: The essential voices"],"prefix":"10.1002","volume":"131","author":[{"given":"Susan K.","family":"Parsons","sequence":"first","affiliation":[{"name":"Department of Medicine Tufts University School of Medicine Tufts Medical Center  Boston Massachusetts USA"},{"name":"Department of Pediatrics Tufts University School of Medicine Tufts Medical Center  Boston Massachusetts USA"},{"name":"Department of Medicine Division of Hematology\/Oncology Institute for Clinical Research and Health Policy Studies  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen E.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison School of Nursing  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julienne","family":"Brackett","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie A.","family":"Devine","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rutgers Cancer Institute  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne M.","family":"Embry","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-2245","authenticated-orcid":false,"given":"Katie A.","family":"Greenzang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"},{"name":"Boston Children\u2019s Cancer and Blood Disorders Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-5863","authenticated-orcid":false,"given":"Philip J.","family":"Lupo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Nu\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences University of Southern California  Los Angeles California USA"},{"name":"Children\u2019s Oncology Group  Monrovia California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7608-607X","authenticated-orcid":false,"given":"Abby R.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Psychosocial Oncology and Palliative Care Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue M.","family":"Zupanec","sequence":"additional","affiliation":[{"name":"Department of Nursing The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-6649","authenticated-orcid":false,"given":"Pamela S.","family":"Hinds","sequence":"additional","affiliation":[{"name":"Department of Nursing Science Professional Practice &amp; Quality Children's National Hospital  Washington District of Columbia USA"},{"name":"Department of Pediatrics George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2021.151163"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.10145"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29702"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454219844225"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.16875"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2022.0134"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djad115"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21637"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201061237\u20102"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28582"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28738"},{"key":"e_1_2_6_13_1","unstructured":"BaschE CampbellA HudgensS et\u00a0al.Broadening the definition of tolerability in cancer clinical trials to better measure the patient experience. Friends of Cancer Research;2020. Accessed January 7 2025.https:\/\/friendsofcancerresearch.org\/publication\/broadening\u2010the\u2010definition\u2010of\u2010tolerability\u2010in\u2010cancer\u2010clinical\u2010trials\u2010to\u2010better\u2010measure\u2010the\u2010patient\u2010experience\/"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00195"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010021\u201006700\u20100"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2022.12.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014\u20102855"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28907"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26981"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2021.0090"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.20.00762"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00012272\u2010199703000\u201000003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454210368532"},{"key":"e_1_2_6_24_1","unstructured":"US Food and Drug Administration (FDA).Guidance Document: Patient\u2010Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims: Guidance for Industry. Department of Health and Human Services FDA Center for Drug Evaluation and Research Center for Biologics Evaluation and Research Center for Devices and Radiological Health;2009. Accessed January 7 2025.https:\/\/www.fda.gov\/regulatory\u2010information\/search\u2010fda\u2010guidance\u2010documents\/patient\u2010reported\u2010outcome\u2010measures\u2010use\u2010medical\u2010product\u2010development\u2010support\u2010labeling\u2010claims"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-25804-7_2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.2868"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2007.10.003"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454209340324"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1188\/18.ONF.290\u2010300"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010022\u201009814\u20108"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2012.10.011"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743291X12Y.0000000035"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000643"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab087"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.04.023"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000963"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000001337"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.03.009"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2015.01.006"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2025.01.004"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2020.10.017"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx250"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24233"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27606"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010022\u201010072\u2010x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30782"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1222"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454220909805"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/ncc.0000000000000721"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000001184"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.02669"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.2861"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454211418666"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30783"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa016"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28160"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2021.06.012"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.11.006"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010021\u201002826\u20100"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010022\u201003259\u2010z"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_390272"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000111"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33740"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3235"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687\u2010023\u201000653\u20100"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280213476378"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.121.007960"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2005.09.006"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac166"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.2196\/14406"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00038"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2337"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31085"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405888"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010022\u201006802\u20103"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.00377"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31133"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010018\u20104713\u20102"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.00910"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(16)00038\u20103"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2024.4727"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.19585"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T14:46:59Z","timestamp":1764427619000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":81,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2025,10,15]]}},"alternative-id":["10.1002\/cncr.35947"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35947","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"2025-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35947"}}