{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:09:32Z","timestamp":1789150172055,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Assessment of sexual dysfunction among adult male survivors of childhood cancer has primarily been limited to erectile dysfunction. This study aimed to characterize sexual functioning more comprehensively among a large population of male survivors of childhood cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male survivors (<jats:italic>N<\/jats:italic>\u00a0=\u00a01595, 22.0\u201359.4 years, median age, 37.8 years) and siblings (<jats:italic>N<\/jats:italic>\u00a0=\u00a0269, 21.5\u201360.8 years, median age, 38.9 years) from the Childhood Cancer Survivor Study completed the Sexual Functioning Questionnaire (SFQ) to assess interest, desire, arousal, satisfaction, activity, orgasm, masturbation, relationship, and problems. Poor sexual functioning was defined as SFQ Total scores &gt;2 standard deviations below siblings' mean. Multivariable logistic regression identified risk factors for poor sexual function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Survivors (8.3%) were more likely to report poor sexual functioning as compared to siblings (4.9%, odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1\u20133.4) and reported lower SFQ total scores (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and lower means on seven subscales. Poor sexual functioning among survivors was associated with older age (40\u201349 years: OR, 3.81; 95% CI, 1.78\u20138.18; 50\u201359 years: OR, 6.45; 95% CI, 2.28\u201318.30), not being married (OR,\u00a04.39; 95% CI, 2.66\u20137.26), lower education (OR, 3.07; 95% CI, 1.32\u20137.14), learning\/memory problems (OR,\u00a01.83; 95% CI, 1.02\u20133.27), and high\u2010dose cranial (\u226540 Gy: OR, 3.45; 95% CI, 1.58\u20137.51) or high\u2010dose testicular (\u226510 Gy: OR,\u00a04.16; 95% CI, 1.66\u201310.39) radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adult male survivors report poor sexual functioning at twice the rate expected before age 60 years. High\u2010dose cranial or testicular radiation, as well as social and cognitive factors, contributes to risk. Improved awareness of sexual dysfunction prevalence and risk factors in male childhood cancer survivors can help clinicians better assess and treat those at highest risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35967","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T12:43:33Z","timestamp":1751633013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive assessment of sexual function in male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-7375","authenticated-orcid":false,"given":"Jordan Gilleland","family":"Marchak","sequence":"first","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Emory University School of Medicine Department of Pediatrics  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy D.","family":"Seidel","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Clinical Statistics and Cancer Prevention Programs  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke O.","family":"Cherven","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Emory University School of Medicine Department of Pediatrics  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-0417","authenticated-orcid":false,"given":"James L.","family":"Klosky","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Emory University School of Medicine Department of Pediatrics  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad W. M.","family":"Ritenour","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Department of Urology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Clinical Statistics and Cancer Prevention Programs  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Sklar","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center Department of Pediatrics  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Psychology Hunter College and The Graduate Center City University of New York  New York New York 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