{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:49:04Z","timestamp":1788922144512,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Opioid exposure during cancer therapy may increase long\u2010term unsafe opioid prescribing. This study sought to determine the rates of coprescription of benzodiazepine and opioid medications and new persistent opioid use after surgical treatment of early\u2010stage cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted among a US veteran population via the Veterans Affairs Corporate Data Warehouse database. Participants were opioid\u2010naive persons aged \u226521 years with a new diagnosis of stage 0\u2013III cancer between January 1, 2015, and December 31, 2016. Outcomes were days of coprescription of benzodiazepines and opioids in the 13 months posttreatment and new persistent opioid use. The exposure was total morphine milligram equivalents (MMEs) attributed to treatment and prescribed from 30 days before through 14 days after the index surgical procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 9213 veterans, coprescription of benzodiazepines and opioids occurred in 366 patients (4.0%) and new persistent opioid use in 981 patients (10.6%). In a linear model adjusting for patient, clinical, and geographic factors, persons in the highest quartile compared to no opioid exposure had increased days with coprescription of benzodiazepines and opioids (mean difference, 1.0; 95% CI, 0.3\u20131.7). In a discrete time survival analysis, persons in the highest quartile of MME exposure compared to none had a greater risk of new persistent opioid use (hazard ratio, 1.6; 95% CI, 1.3\u20131.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>More than one of 10 opioid\u2010naive veterans undergoing curative\u2010intent surgical treatment for cancer developed new persistent opioid use. Optimizing cancer treatment pain management strategies to mitigate long\u2010term opioid\u2010related health risks is crucial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70009","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T07:01:08Z","timestamp":1757314868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of opioid use associated with curative\u2010intent cancer surgery on safe opioid prescribing practice among veterans: An observational study"],"prefix":"10.1002","volume":"131","author":[{"given":"Marilyn M.","family":"Schapira","sequence":"first","affiliation":[{"name":"Center for Healthcare Evaluation, Research, and Promotion Corporal Michael J. Crescenz Veterans Affairs (VA) Medical Center  Philadelphia Pennsylvania USA"},{"name":"Department of Medicine Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"The Leonard Davis Institute of Health Economics University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumedha","family":"Chhatre","sequence":"additional","affiliation":[{"name":"Center for Healthcare Evaluation, Research, and Promotion Corporal Michael J. Crescenz Veterans Affairs (VA) Medical Center  Philadelphia Pennsylvania USA"},{"name":"The Leonard Davis Institute of Health Economics University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patience M.","family":"Dow","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Groeneveld","sequence":"additional","affiliation":[{"name":"Center for Healthcare Evaluation, Research, and Promotion Corporal Michael J. Crescenz Veterans Affairs (VA) Medical Center  Philadelphia Pennsylvania USA"},{"name":"Department of Medicine Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"The Leonard Davis Institute of Health Economics University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-9737","authenticated-orcid":false,"given":"Jason M.","family":"Prigge","sequence":"additional","affiliation":[{"name":"Center for Healthcare Evaluation, Research, and Promotion Corporal Michael J. Crescenz Veterans Affairs (VA) Medical Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Roberts","sequence":"additional","affiliation":[{"name":"Center for Healthcare Evaluation, Research, and Promotion Corporal Michael J. Crescenz Veterans Affairs (VA) Medical Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary F.","family":"Meisel","sequence":"additional","affiliation":[{"name":"The Leonard Davis Institute of Health Economics University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Emergency Medicine Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi B.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravishankar","family":"Jayadevappa","sequence":"additional","affiliation":[{"name":"Center for Healthcare Evaluation, Research, and Promotion Corporal Michael J. 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