{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:18:25Z","timestamp":1785557905106,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Glioblastoma (GBM) is the most common primary brain malignancy, and standard treatment includes maximal resection of contrast\u2010enhancing tumor. Given recent interest in resection beyond areas of contrast\u2010enhancement, the authors analyzed the role of peri\u2010tumoral resection (PTR) in primary GBM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 126 adult patients with primary GBM amenable to peri\u2010tumoral resection (PTR) at a tertiary care academic medical center. Patient characteristics and pre\/postoperative tumor volumes were collected. Outcome\u2010oriented cut\u2010points for extent of resection of contrast\u2010enhancing tumor (EOR) were determined using maximally selected rank statistics. Multivariable Cox proportional hazards (CPH) model for death was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This cohort had mean age 60.7\u00a0\u00b1\u00a011.3 years and median overall survival (OS)\/progression\u2010free survival (PFS) 15.2\/7.5 months. EOR &gt;92.1% was associated with increased OS compared to &lt;92.1% EOR (23.1 vs.14.0 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Fifty\u2010four (42%) patients received PTR, of which 28 (22%) achieved PTR of &gt;1.74 cm\n                      <jats:sup>3<\/jats:sup>\n                      beyond the contrast\u2010enhancing region. This latter group demonstrated greater OS than the PTR&lt;1.74 cm\n                      <jats:sup>3<\/jats:sup>\n                      group (21.6 vs. 16.8 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). There was no significant difference in postoperative complications between groups. Multivariable CPH model found EOR 92.1%\u201399% (hazard ratio [HR], 0.30; confidence interval [CI], 0.15\u20130.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) and PTR &gt;1.74 cm\n                      <jats:sup>3<\/jats:sup>\n                      (HR, 0.27; CI, 0.13\u20130.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) were associated with increased OS. Preoperative T2\u2010FLAIR volume &gt;192 cm\n                      <jats:sup>3<\/jats:sup>\n                      was associated with worse OS (HR, 3.18; CI, 1.17\u20138.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our results demonstrate increased OS in GBM with resection beyond contrast\u2010enhancing tumor margins. With no associated increase in postoperative deficits, PTR &gt;1.74 cm\n                      <jats:sup>3<\/jats:sup>\n                      was both effective and safe in select cases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70016","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:54:17Z","timestamp":1753354457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of peri\u2010tumoral resection on survival in primary glioblastoma"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-5378","authenticated-orcid":false,"given":"Linda Y.","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Botros","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya A.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adham M.","family":"Khalafallah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden","family":"Dux","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8651-1321","authenticated-orcid":false,"given":"Nauman","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuncong","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paarth","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calixto\u2010Hope G.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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