{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T02:02:51Z","timestamp":1770688971905,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Splicing factor 3b subunit 1 (\n SF3B1<\/jats:italic>\n ) mutations have been implicated in hematologic malignancies, but the clinical significance of distinct\n SF3B1<\/jats:italic>\n mutation variants remain unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The objective of this study was to evaluate clinicopathologic features, mutational profiles, and outcomes of 1691 patients with hematologic malignancies, including myelodysplastic syndromes (MDS;\n n<\/jats:italic>\n \u00a0=\u00a0402), acute myeloid leukemia (AML;\n n<\/jats:italic>\n \u00a0=\u00a0758), and chronic lymphocytic leukemia (CLL;\n n<\/jats:italic>\n \u00a0=\u00a0531).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The frequency of\n SF3B1<\/jats:italic>\n \u2010mutated (\n SF3B1<\/jats:italic>\n MUT<\/jats:sup>\n ) MDS, AML, and CLL was 70 of 402 patients (17.4%), 23 of 758 patients (3.0%), and 45 of 531 patients (8.5%), respectively. p.K700E was the most prevalent\n SF3B1<\/jats:italic>\n MUT<\/jats:sup>\n variant and was identified in 43 of 70 of patients with MDS (61.4%), in seven of 23 patients with AML (30.4%), and in 19 of 45 patients with CLL (42.2%). In MDS and AML,\n TET2<\/jats:italic>\n was the most frequent co\u2010mutated gene in patients with\n SF3B1<\/jats:italic>\n MUT<\/jats:sup>\n disease (20 of 70 patients with MDS [28.6%]; 11 of 23 patients with AML [47.8%]). For patients with\n SF3B1<\/jats:italic>\n MUT<\/jats:sup>\n CLL, the most common co\u2010mutated genes were\n ATM<\/jats:italic>\n (11 of 45; 24.4%) and\n TP53<\/jats:italic>\n (11 of 45; 24.4%). Kaplan\u2013Meier analysis indicated that the\n SF3B1<\/jats:italic>\n p.K700E variant was significantly associated with improved overall survival (OS) and progression\u2010free survival (PFS) in patients who had MDS (\n p\u00a0<<\/jats:italic>\n \u00a0.001 and\n p<\/jats:italic>\n \u00a0=\u00a0.016, respectively) but with worse OS and PFS in those who had AML (\n p<\/jats:italic>\n \u00a0=\u00a0.006 and\n p<\/jats:italic>\n \u00a0=\u00a0.006, respectively) compared with those who had wild\u2010type\n SF3B1<\/jats:italic>\n . In patients who had CLL, p.I704F was associated with reduced OS (\n p<\/jats:italic>\n \u00a0<\u00a0.001) and p.K700E was associated with a shorter time\u2010to\u2010first treatment (\n p<\/jats:italic>\n \u00a0=\u00a0.028) compared with those who had wild\u2010type\n SF3B1<\/jats:italic>\n . Multivariable analysis identified p.K700E as an independent protective factor for OS in patients with MDS (\n p<\/jats:italic>\n \u00a0=\u00a0.048) but as an independent risk factor for both OS and PFS in patients with AML (\n p<\/jats:italic>\n \u00a0=\u00a0.036 and\n p<\/jats:italic>\n \u00a0=\u00a0.035, respectively) and for the time to first treatment in patients with CLL (\n p<\/jats:italic>\n \u00a0=\u00a0.033).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Specific\n SF3B1<\/jats:italic>\n variants should be incorporated into prognostic stratification for hematologic malignancies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cncr.70017","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T13:04:58Z","timestamp":1753189498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Splicing factor 3b subunit 1 mutation patterns and prognostic implications in myelodysplastic syndromes, acute myeloid leukemia, and chronic lymphocytic leukemia: A retrospective study of 1691 cases"],"prefix":"10.1002","volume":"131","author":[{"given":"Chun","family":"Qiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing China"},{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine Nanjing China"},{"name":"Department of Hematology Lymphoma Center The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine Nanjing China"},{"name":"Department of Hematology Lymphoma Center The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine Nanjing China"},{"name":"Department of Hematology Lymphoma Center The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing 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