{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:14:29Z","timestamp":1789996469841,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastroenteropancreatic neuroendocrine neoplasms (GEP\u2010NENs) account for more than 50% of all NENs. The survival of patients with GEP\u2010NENs has improved based on early diagnosis and improved treatment strategies. The real\u2010world data of GEP\u2010NENs in Taiwan are limited. A multicenter registry study was conducted to obtain real\u2010world data on GEP\u2010NENs in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with pathologically diagnosed GEP\u2010NENs were enrolled. Data were on the baseline characteristics, treatment strategies, and patient survival. Also evaluated was the expression status of six biomarkers, including SSTR2, SSTR5, PDX\u20101, CDX\u20102, mASH1, and NeuroD, in tumors. Overall survival (OS) was analyzed and plotted via the Kaplan\u2013Meier method. Cox regression analysis was used to analyze the prognostic factors of OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 600 GEP\u2010NEN patients were enrolled. Pancreatic NENs accounted for 43.0% of all patients. The 5\u2010year and 10\u2010year OS rates of all patients were 70.9% and 61.3%, respectively. In the multivariable Cox regression analysis, older age (hazard ratio [HR]\u00a0=\u00a01.02; 95% CI, 1.01\u20131.03), higher Eastern Cooperative Oncology Group performance status score, higher tumor grade (World Health Organization classification) and stage 4 disease (HR\u00a0=\u00a06.22; 95% CI, 3.60\u201310.76) were associated with poor OS. Positive SSTR2 expression (HR\u00a0=\u00a00.53; 95% CI, 0.31\u20130.91) was associated with better OS according to multivariate Cox regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides real\u2010world data on 600 GEP\u2010NENs in Taiwan and identifies age, Eastern Cooperative Oncology Group performance status score, tumor grade, tumor stage, and SSTR2 expression as prognostic factors for the survival of GEP\u2010NENs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70019","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:13:09Z","timestamp":1755691989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical outcomes of gastroenteropancreatic neuroendocrine neoplasms in Taiwan: A multicenter registry study\u2014TCOG T1214 study"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5246-5748","authenticated-orcid":false,"given":"Hui\u2010Jen","family":"Tsai","sequence":"first","affiliation":[{"name":"National Institute of Cancer Research National Health Research Institutes  Tainan Taiwan"},{"name":"Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Division of Hematology and Oncology Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Huang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Po","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Fu","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences National Health Research Institutes  Zhunan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-3974","authenticated-orcid":false,"given":"Jen\u2010Shi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Linkou Chang\u2010Gung Memorial Hospital &amp; Chang\u2010Gung University  Tao\u2010yuan City 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China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Chuan","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of General Surgery Department of Surgery Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Yi","family":"Chu","sequence":"additional","affiliation":[{"name":"National Institute of Cancer Research National Health Research Institutes  Tainan Taiwan"},{"name":"Department of Pathology Show Chwan Memorial Hospital  Changhua Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Liang","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Internal Medicine Tri\u2010Service General 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