{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:01:16Z","timestamp":1791558076198,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["U01FD005938"],"award-info":[{"award-number":["U01FD005938"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Opioid stewardship policies could adversely affect pain management for patients with cancer. Yet patients with cancer are also at risk for opioid\u2010related harms. This study sought to determine trends in opioid prescribing by clinical stratum and pain for patients with cancer from 2016 to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective study was conducted of opioid\u2010naive adults with newly diagnosed cancer from 2016 to 2020 (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a010,232) in a large Connecticut health system. Logistic regression was used to calculate changes in the predicted probability of opioid prescribing from 2016 to 2020. Two subpopulations were examined: patients treated surgically (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04405) and patients with metastatic cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02158). Flowsheet pain scores for patients with metastatic cancer were used to stratify by no pain (all scores,\u00a00) versus any pain. The main outcomes were new (\u22651 prescription in the 0\u20136 months after diagnosis) and additional (0\u20136 and 7\u20139 months) opioid prescriptions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A decline was observed in the predicted probability of new (71.1% to 64.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and additional prescribing (27.2% to 24.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.07 [not significant]) declined. Among surgical patients, the predicted probability of new opioid prescribing fell (96.0% to 88.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), whereas additional prescribing was stable (13%). For patients with metastatic cancer with pain, new opioid prescribing was stable (56%). For those reporting no pain, the predicted probability of new opioid prescribing declined from 61.6% to 36.1% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the context of widespread policy changes, this study showed a modest decline in new and additional opioid prescribing for patients with cancer. In metastatic cancer, prescribing remained stable for patients reporting pain and declined steeply for those reporting no pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70027","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T07:01:24Z","timestamp":1758524484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Opioid prescribing trends and pain scores among adult patients with cancer in a large health system"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-6213","authenticated-orcid":false,"given":"Laura Van Metre","family":"Baum","sequence":"first","affiliation":[{"name":"Department of Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale School of Medicine  New Haven Connecticut 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