{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:30:48Z","timestamp":1785501048541,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Octa\u2010nonagenarians with acute myeloid leukemia (AML) represent a high\u2010risk group due to frequently poor performance status, adverse genomics (e.g., <jats:italic>TP53<\/jats:italic> mutations, complex karyotype), a high incidence of secondary AML, and inability to undergo an allogeneic stem cell transplantation. Evaluating their outcomes with modern treatment approaches is important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed outcomes of patients \u226580 years old with newly diagnosed AML treated at our center from 2013\u20132023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 289 patients (median age, 83 years; range, 80\u201395 years) were included. Venetoclax containing low\u2010intensity therapy was administered to 107 patients (37.0%). AML subtypes included de novo (123, 42.6%), secondary (114, 39.4% [82 treated\u2014secondary, 32 untreated\u2014secondary]), therapy\u2010related without prior myeloid neoplasm (40, 13.8%), and post\u2010myeloproliferative neoplasm AML (12, 4.3%). Composite complete response (CRc) was achieved in 43.2%, with higher rates in venetoclax\u2010treated patients (61.7% vs. 32.4%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Median relapse\u2010free survival among patients with a CRc was 6.5 months. Median overall survival (OS) was 6.2 months; 13.7 months for those achieving CRc. One\u2010year nonrelapse mortality was 18.4%. Median OS was 7.7 months with venetoclax versus 5.4 months without. In de novo AML, median OS with venetoclax was 11.1 months. Among venetoclax\u2010treated patients, favorable subgroups (e.g., <jats:italic>NPM1<\/jats:italic> and\/or <jats:italic>IDH1\/2<\/jats:italic> mutations and\/or myelodysplasia related mutations without <jats:italic>TP53<\/jats:italic> mutation and adverse cytogenetics) achieved OS up to 16.0\u201316.3 months. On multivariate analysis, de novo AML, wild\u2010type <jats:italic>TP53<\/jats:italic>, and venetoclax therapy were independently associated with improved OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010intensity venetoclax\u2010based regimens offer meaningful survival benefits in selected octa\u2010nonagenarian patients with AML, particularly those with favorable genomic profiles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.70028","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T10:33:24Z","timestamp":1754562804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Contemporary outcomes of octa\u2010nonagenarians with newly diagnosed acute myeloid leukemia"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6831-2567","authenticated-orcid":false,"given":"Jayastu","family":"Senapati","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-3307","authenticated-orcid":false,"given":"Hagop M.","family":"Kantarjian","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-9832","authenticated-orcid":false,"given":"Tapan M.","family":"Kadia","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas 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