{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:11:34Z","timestamp":1783131094159,"version":"3.54.6"},"reference-count":63,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,8,15]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>This study examined the impact of measurable residual disease (MRD) dynamics in adults with lysine methyltransferase 2a rearrangement (KMT2A<\/jats:italic>r) in acute myeloid leukemia (AML) during the peritransplant period (before and early after allogeneic hematopoietic stem cell transplantation [HSCT]).<\/jats:p><\/jats:sec>Methods<\/jats:title>This study involved 144 adult patients with AML with KMT2A<\/jats:italic>r who underwent HSCT between 2015 and 2024. Patients were enrolled if they survived without relapse for at least 3 months post\u2010HSCT. MRD was measured via real\u2010time quantitative polymerase chain reaction.<\/jats:p><\/jats:sec>Results<\/jats:title>The cohort was categorized into four groups on the basis of MRD status before and after HSCT, respectively: MRD negative\/MRD negative (n<\/jats:italic>\u00a0=\u00a081), MRD negative\/MRD positive (n<\/jats:italic>\u00a0=\u00a02), MRD positive\/MRD negative (n<\/jats:italic>\u00a0=\u00a043), and MRD positive\/MRD positive (n<\/jats:italic>\u00a0=\u00a018). Significant differences were found in 3\u2010year overall survival (OS), leukemia\u2010free survival (LFS), and cumulative incidence of relapse (CIR) (all p\u00a0<<\/jats:italic>\u00a0.001), with the MRD\u2010negative\/MRD\u2010negative group having the best outcomes (88% OS, 85% LFS, and 10% CIR), whereas the MRD\u2010negative\/MRD\u2010positive group (0% OS, 0% LFS, and 100% CIR) and MRD\u2010positive\/MRD\u2010positive group (29% OS, 31% LFS, and 69% CIR) had the worst outcomes. The MRD\u2010positive\/MRD\u2010negative group had an intermediate prognosis (63% OS, 58% LFS, and 32% CIR). Peri\u2010HSCT MRD dynamics served as an independent factor, which distinguished patient groups with differential risk probabilities of mortality and relapse. C<\/jats:italic>\u2010statistic values were greater when peri\u2010HSCT MRD dynamic testing was used than when isolated pre\u2010 or post\u2010HSCT MRD was used to predict CIR (0.68 vs. 0.58 vs. 0.56), LFS (0.74 vs. 0.69 vs. 0.64), and OS (0.73 vs. 0.68 vs. 0.66).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Compared with single\u2013time point MRD assessments, peritransplant MRD dynamics confer superior prognostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.70044","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:19:47Z","timestamp":1755098387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peritransplant lysine methyltransferase 2a\u2013rearranged measurable residual disease dynamics as a prognostic marker in adult acute myeloid leukemia"],"prefix":"10.1002","volume":"131","author":[{"given":"Lu\u2010Lu","family":"Wang","sequence":"first","affiliation":[{"name":"Peking University People\u2019s Hospital Peking University Institute of Hematology Beijing China"},{"name":"National Clinical Research Center for Hematologic Disease Beijing China"},{"name":"Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital Peking University Institute of Hematology Beijing China"},{"name":"National Clinical Research Center for Hematologic Disease Beijing China"},{"name":"Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing 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