{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:31:47Z","timestamp":1792031507896,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003083","name":"European Association of Urology","doi-asserted-by":"publisher","award":["S\u20102022\u20100003"],"award-info":[{"award-number":["S\u20102022\u20100003"]}],"id":[{"id":"10.13039\/501100003083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study assesses the incidence and timing of undetectable prostate\u2010specific antigen (PSA) after radiotherapy (RT)\u00a0\u00b1\u00a0androgen deprivation therapy (ADT) and its association with prostate cancer mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a population\u2010based study including 5299 men undergoing RT (2006\u20132020) in the Stockholm County, Sweden with all their PSA tests until death or emigration. The authors calculated incidence and timing of undetectable PSA (PSA \u22640.1 ng\/mL) and used competing risk regression to evaluate the association of detectable PSA at 6 and 12 months with prostate cancer mortality (PCSM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up for survivors was 81 (32, 130) months. PSA nadir values were reached before 6 and 12 months in 233 (23%) and 470 (36%) patients undergoing RT and 2871 (85%) and 3612 (90%) patients undergoing RT+ADT. No significant association was found between PSA at nadir, 6 and 12 months and PCSM in the radiotherapy group and evidence of association with higher PCSM in RT+ADT group (PSA at nadir: subdistribution hazard ratio [sHR], 2.23 [2.01\u20132.49]; PSA at 6 months: sHR, 6.91 [5.17\u20139.23]; and PSA at 12 months: sHR, 37.9 [23.0\u201362.5]). At 12 years after RT + ADT, PCSM rates were 27%, 15%, 13%, and 5% for patients with PSA at 6 months of \u22650.5, 0.2\u20130.5, 0.1\u20130.2, and \u22640.1 ng\/mL, respectively; corresponding rates by PSA at 12 months were 34%, 18%, 12%, and 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most patients undergoing RT+ADT reached a PSA \u22640.1 ng\/mL within 6 and 12 months. PSA&gt;0.1 ng\/mL at these time points indicated a higher risk of PCSM, emphasizing the need for timely restaging and intensified salvage treatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.70045","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T09:00:17Z","timestamp":1755421217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Detectable prostate\u2010specific antigen after radiotherapy for clinically localized prostate cancer"],"prefix":"10.1002","volume":"131","author":[{"given":"Ugo Giovanni","family":"Falagario","sequence":"first","affiliation":[{"name":"Department of Urology and Kidney Transplantation University of Foggia  Foggia Italy"},{"name":"Department of Molecular Medicine and Surgery, (Solna) Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, (Solna) Karolinska Institutet  Stockholm Sweden"},{"name":"Unit of Urology\/Division of Oncology Soldera Prostate Cancer Lab Urological Research Institute IRCCS San Raffaele Hospital, Milan, Italy Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Abbadi","sequence":"additional","affiliation":[{"name":"Departments of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bj\u00f6rnebo","sequence":"additional","affiliation":[{"name":"Departments of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7281-0991","authenticated-orcid":false,"given":"Alexander","family":"Valdman","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Hjelm","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Oncology St. G\u00f6ran Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Zelic","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, (Solna) Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carrieri","sequence":"additional","affiliation":[{"name":"Department of Urology and Kidney Transplantation University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Gandaglia","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology Soldera Prostate Cancer Lab Urological Research Institute IRCCS San Raffaele Hospital, Milan, Italy Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology Soldera Prostate Cancer Lab Urological Research Institute IRCCS San Raffaele Hospital, Milan, Italy Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montorsi","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology Soldera Prostate Cancer Lab Urological Research Institute IRCCS San Raffaele Hospital, Milan, Italy Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Aly","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, (Solna) Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorgerdur","family":"Palsdottir","sequence":"additional","affiliation":[{"name":"Departments of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Eklund","sequence":"additional","affiliation":[{"name":"Departments of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Departments of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Gr\u00f6nberg","sequence":"additional","affiliation":[{"name":"Departments of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Akre","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, (Solna) Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wiklund","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, (Solna) Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Urology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lantz","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, (Solna) Karolinska Institutet  Stockholm Sweden"},{"name":"Departments of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710083171501"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724\u20106051.23.05395\u20108"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.04.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaf012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.04.029"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.06.025"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.11.056"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00762"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.03.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003518"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2020.1739139"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010017\u20100316\u20101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010019\u201002780\u20104"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0400400201"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.4970"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(11)70295\u20109"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31400"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5983"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.06.011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2024.09.015"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.01.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2024.11.008"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:44:02Z","timestamp":1760406242000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.70045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":23,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,15]]}},"alternative-id":["10.1002\/cncr.70045"],"URL":"https:\/\/doi.org\/10.1002\/cncr.70045","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"assertion":[{"value":"2025-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70045"}}