{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:11:09Z","timestamp":1789996269198,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023Y0020"],"award-info":[{"award-number":["2023Y0020"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Targeted axillary dissection (TAD) is used for less\u2010invasive axillary staging in patients with initially node\u2010positive breast cancer undergoing neoadjuvant chemotherapy (NACT). However, the efficacy of TAD using carbon suspension remains unclear. Here, the aim was to evaluate the feasibility and accuracy of TAD, combining sentinel lymph node biopsy (SLNB) using a single blue dye tracer with target lymph node biopsy (TLNB) using carbon suspension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective single\u2010institution study enrolled patients with biopsy\u2010proven T1 to 3 N1 to 3 breast cancer between March 2020 and December 2022. Pre\u2010NACT, black carbon suspension was injected into pathologically confirmed positive axillary lymph nodes. Post\u2010NACT, single tracer\u2013based SLND combined with TLNB was performed, followed by axillary lymph node dissection. Detection rates, false\u2010negative rates, and negative predictive values were calculated for TAD, SLNB, and TLNB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 268 patients enrolled, 254 were included in the final evaluation, of which 86 and 93 had cN2\/3 and HER2\u2010positive disease, respectively. Detection rates were SLNB, 87.4%; TLNB, 96.9%; and TAD, 85.4%. The overall axillary pathological complete response rate was 42.1% (107 patients). False\u2010negative rates were SLNB, 7.8%; TLNB, 12.7%; and TAD, 6.3%, with negative predictive values of 90.3%, 85.1%, and 91.9%, respectively. In seven of eight false\u2010negative TAD cases, only one had lymph node metastasis; most showed micrometastases or isolated tumor cells. Retrieving\u2009\u22653 lymph nodes using TAD reduced the false\u2010negative rates to 3.8%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TAD based on carbon suspension marking and single blue dye tracer is feasible and accurate for axillary staging in initially pN+\u00a0patients with breast cancer post\u2010NACT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Neoadjuvant chemotherapy is often used for patients with breast cancer who have positive lymph nodes. This study aimed to check if a method called targeted axillary dissection, involving the use of carbon suspension and a blue dye, is effective in identifying biopsied nodes. The researchers marked lymph nodes with carbon before treatment and performed surgeries after chemotherapy. The results showed that targeted axillary dissection is a feasible and accurate method to identify positive lymph nodes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70047","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T16:29:12Z","timestamp":1755620952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility and accuracy of targeted axillary dissection by carbon tattooing in biopsy\u2010proven node\u2010positive breast cancer: A prospective study"],"prefix":"10.1002","volume":"131","author":[{"given":"Minyan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Fujian Medical University Union Hospital  Fuzhou, Fujian Fujian Province China"},{"name":"Department of General Surgery Fujian Medical University Union Hospital  Fuzhou, Fujian Fujian Province China"},{"name":"Breast Cancer Institute Fujian Medical 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Union Hospital  Fuzhou, Fujian Fujian Province China"},{"name":"Breast Cancer Institute Fujian Medical University  Fuzhou, Fujian Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Fujian Medical University Union Hospital  Fuzhou, Fujian Fujian Province China"},{"name":"Department of General Surgery Fujian Medical University Union Hospital  Fuzhou, Fujian Fujian Province China"},{"name":"Breast Cancer Institute Fujian Medical University  Fuzhou, Fujian Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Fujian Medical University Union Hospital  Fuzhou Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of 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