{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:12:37Z","timestamp":1789996357496,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Venetoclax (VEN) in combination with azacitidine (AZA) (VEN\u2010AZA) is used to treat acute myeloid leukemia (AML) in patients who are not candidates for intensive chemotherapy but research on prognostic factors remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Measurable residual disease (MRD) by multiparametric flow cytometry in AML is important but there is limited evidence of the clinical utility of monitoring MRD in patients treated with VEN\u2010AZA. Herein, a total of 75 patients newly diagnosed with AML treated with VEN\u2010AZA were retrospectively analyzed to examine the role and timing of MRD to predict survival. MRD enabled the categorization of patients into two groups: Day 14 MRD, &gt;1% (MRD\n                      <jats:sup>14\u2010pos<\/jats:sup>\n                      ); and Day 14 MRD, \u22641% (MRD\n                      <jats:sup>14\u2010neg<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 75 patients, 31 (41.3%) had MRD\n                      <jats:sup>14\u2010neg<\/jats:sup>\n                      , whereas 30 (40.0%) had not achieved complete remission (CR) after induction. MRD\n                      <jats:sup>14\u2010neg<\/jats:sup>\n                      was associated with improved overall survival (OS) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.024) and event\u2010free survival (EFS) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.044). In addition, MRD\n                      <jats:sup>14\u2010neg<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002 for both OS and EFS),\n                      <jats:italic>CSF3R<\/jats:italic>\n                      negative (\n                      <jats:italic>CSF3R<\/jats:italic>\n                      <jats:sup>neg<\/jats:sup>\n                      ) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001 for both OS and EFS), and transplantation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.005 for OS;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.007 for EFS) were associated with improved survival outcomes. Further subgroup analysis revealed that MRD\n                      <jats:sup>14\u2010pos<\/jats:sup>\n                      patients who underwent transplantation showed a trend toward longer OS and EFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001 for both).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Results in the MRD\n                      <jats:sup>14\u2010neg<\/jats:sup>\n                      group were better than in the MRD\n                      <jats:sup>14\u2010pos<\/jats:sup>\n                      group, and the prognosis for patients with AML was better when there was\n                      <jats:italic>CSF3R<\/jats:italic>\n                      <jats:sup>neg<\/jats:sup>\n                      and transplantation. Additionally, for patients with AML with MRD\n                      <jats:sup>14\u2010pos<\/jats:sup>\n                      , consolidation with transplantation may increase survival.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70053","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T10:52:24Z","timestamp":1756205544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of Day 14 measurable residual disease in acute myeloid leukemia treated with venetoclax and azacitidine"],"prefix":"10.1002","volume":"131","author":[{"given":"Jiaying","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxu","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzhi","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2960-3131","authenticated-orcid":false,"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University 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