{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:12:37Z","timestamp":1789996357114,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Methods<\/jats:title>\n                    <jats:p>This real\u2010world study evaluated the clinical effectiveness of gilteritinib in 205 patients with relapsed or refractory (R\/R) FLT3\u2010mutated acute myeloid leukemia (AML) enrolled in the Italian expanded access since January 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 205 patients, 124 (60.5%) received gilteritinib as a bridging therapy to allogeneic stem cell transplantation (allo\u2010SCT), achieving complete remission in 52.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a065). The median overall survival (OS) for the entire cohort was 11.0 months, with estimated OS rates of 46.8% at 1 year and 28.5% at 3 years. Sixty patients (48% of those bridged) underwent allo\u2010SCT after a median of 3.7 months on gilteritinib, achieving posttransplant OS rates of 65.2% at 1 year and 56.1% at 3 years. The acquisition of FLT3 mutations at relapse and the presence of TP53 co\u2010mutations were significantly associated with inferior outcomes. Among 46 patients (22.4%) who relapsed after allo\u2010SCT, gilteritinib treatment yielded an overall response rate (ORR) of 54.3%, a median OS of 11.1 months, and 1\u2010 and 3\u2010year OS rates of 49.5% and 15.5%, respectively. Additionally, 35 patients (17.1%) previously treated with nonintensive chemotherapy received gilteritinib until disease progression or intolerance, achieving an ORR of 11.4%, a median OS of 5.9 months, and a 1\u2010year OS rate of 29.0%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These real\u2010world data confirm that clinical outcomes achieved with gilteritinib in patients with R\/R FLT3\u2010mutated AML are consistent with those observed in pivotal clinical trials. Notably, approximately half of the transplant\u2010eligible patients were successfully bridged to allo\u2010SCT and demonstrated encouraging long\u2010term survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70055","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:04:22Z","timestamp":1755792262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gilteritinib in FLT3\u2010mutated acute myeloid leukemia: A real\u2010world Italian experience"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-2623","authenticated-orcid":false,"given":"Roberto","family":"Cairoli","sequence":"first","affiliation":[{"name":"Department of Hematology ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"},{"name":"Department of Medicine and Surgery University of Milano Bicocca  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Del Castello","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovation Bicocca Bioinformatics Biostatistics and Bioimaging Center B4 School of Medicine and Surgery University of Milano\u2010Bicocca, Monza, Italy ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Imbergamo","sequence":"additional","affiliation":[{"name":"Department of Medicine Hematology and Clinical Immunology Unit University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Pierdomenico","sequence":"additional","affiliation":[{"name":"Hematology Unit Istituto Oncologico Veneto IRCCS  Castelfranco Veneto Province of Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-8333","authenticated-orcid":false,"given":"Cristina","family":"Papayannidis","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia \u201cSeragnoli\u201d IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-3817","authenticated-orcid":false,"given":"Erika","family":"Borlenghi","sequence":"additional","affiliation":[{"name":"Department of Hematology ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogero","family":"Vetro","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Ospedaliera dell'Alto Adige  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-1587","authenticated-orcid":false,"given":"Patrizia","family":"Chiusolo","sequence":"additional","affiliation":[{"name":"Hematology Unit Universit\u00e0 Cattolica Del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplant Unit Ospedale San Gerardo  Monza Province of Monza and Brianza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Minotti","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-2272","authenticated-orcid":false,"given":"Francesco","family":"Marchesi","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Unit IRCCS\u2010Regina Elena National Cancer Institute Istituti Fisioterapici Ospitalieri (IFO)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pellegrino","family":"Musto","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area \u201cAldo Moro\u201d University School of Medicine, and Unit of Hematology and Stem Cell Transplantation AOUC Policlinico  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Fracchiolla","sequence":"additional","affiliation":[{"name":"SC Ematologia Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Candoni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Modena and Reggio Emilia Italy  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Lunghi","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Translational Medicine University of Eastern Piedmont  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Musso","sequence":"additional","affiliation":[{"name":"Hematology Unit Clinica La Maddalena Division of Onco\u2010Hematology and Stem Cell Transplantation  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Guolo","sequence":"additional","affiliation":[{"name":"Hematology Unit Clinic of Hematology Department of Internal Medicine (DiMI) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Mannina","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Ospedali Riuniti Papardo Piemonte  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albana","family":"Lico","sequence":"additional","affiliation":[{"name":"Hematology Unit San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Scattolin","sequence":"additional","affiliation":[{"name":"Hematology Unit Ospedale Dell'Angelo  Mestre Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Crugnola","sequence":"additional","affiliation":[{"name":"Hematology Unit University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Hematology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"Nadali","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Ospedaliera di Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Turrini","sequence":"additional","affiliation":[{"name":"Section of Hematology Valduce Hospital  Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Zappasodi","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Todisco","sequence":"additional","affiliation":[{"name":"Division of Hematology ASST Valleolona Ospedale di Busto Arsizio  Busto Arsizio Province of Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Basilico","sequence":"additional","affiliation":[{"name":"Division of Hematology ASST Settelaghi Ospedale di Circolo  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Grillo","sequence":"additional","affiliation":[{"name":"Department of Hematology ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Hematology ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Riva","sequence":"additional","affiliation":[{"name":"Department of Hematology ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide Paolo","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovation Bicocca Bioinformatics Biostatistics and Bioimaging Center B4 School of Medicine and Surgery University of Milano\u2010Bicocca, Monza, Italy ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Hematology ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13161392"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2021.106727"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1406184"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12206429"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081768"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010017\u20100470\u2010z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(17)30416\u20103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1902688"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyac069"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000174"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019\u20100976"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001742\u20107"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26447"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014017"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010022\u201004895\u20108"},{"key":"e_1_2_9_17_1","unstructured":"KunadtD ZukunftS R\u00f6lligC et\u00a0al.Gilteritinib and allogeneic hematopoietic stem cell transplantation improve outcome in relapsed\/refractory FLT3\u2010mutated acute myeloid leukemia patients: real\u2010world data from a multicenter analysis.Paper presented at: 49th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT);2023; OS01\u201001."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2023.031"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201008\u2010733196"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.303"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(24)00098\u2010x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16234028"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201000964\u20105"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17091586"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.cd\u201018\u20101453"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.70055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:49:51Z","timestamp":1789994991000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.70055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":25,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,9,1]]}},"alternative-id":["10.1002\/cncr.70055"],"URL":"https:\/\/doi.org\/10.1002\/cncr.70055","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"2025-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70055"}}