{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:41:24Z","timestamp":1793054484687,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The response to ruxolitinib after 6 months (RR6) model allows early identification of ruxolitinib\u2010treated myelofibrosis (MF) patients with poorer overall survival (OS); however, it is less applicable to lower\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To further explore this, the authors performed a subanalysis of the \u201cRUX\u2010MF\u201d study (NCT06516406) with an aim to validate the RR6 and to develop a score specific for intermediate\u20101 DIPSS\/MYSEC\u2010PM risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 776 evaluable patients, 34.4%, 47.8%, and 17.8% were at low, intermediate, and high RR6 risk, with 5\u2010year OS of 64.1%, 51.8%, and 44.5%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). In the 428 intermediate\u20101 patients, the RR6 model did not discriminate between intermediate and low\u2010risk patients (5\u2010year OS: 74.4% vs. 72.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.24). The intermediate\u20101 specific RR6 (iRR6) model was therefore developed by incorporating new variables: underdosed ruxolitinib with respect to platelet count at one or more time points (hazard ratio [HR], 3.91;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), absence of palpable spleen reduction by\u00a0\u226550% at 6 months (HR, 1.45;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.02), and red blood cell transfusion requirement at all time points (HR, 1.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01). The iRR6 model stratified patients into three risk categories: low (score 0, 20.3%), intermediate (score 1\u20132, 45.8%), and high\u2010risk (score &gt;2, 33.9%), with 5\u2010year OS of 84.8%, 76.4%, and 56.6%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001). The iRR6 model was validated in a cohort of 95 intermediate\u20101 risk patients from the Moffitt Cancer Center, yielding stratification into the same three risk categories, with 5\u2010year OS of 83.3% (low\u2010risk), 71.7% (intermediate\u2010risk), and 54.5% (high\u2010risk) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The iRR6 model provides a more refined tool for the identification of intermediate\u20101 MF patients who may benefit from early therapy shift.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70062","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:08:23Z","timestamp":1755792503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Revised \u201ciRR6\u201d model in intermediate\u20101 risk myelofibrosis patients treated with ruxolitinib"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-5668","authenticated-orcid":false,"given":"Francesca","family":"Palandri","sequence":"first","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Branzanti","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Specialistica Diagnostica e Sperimentale Universit\u00e0 di Bologna  Bologna 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