{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:27:15Z","timestamp":1790036835099,"version":"4.0.1"},"reference-count":107,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA263317"],"award-info":[{"award-number":["K08CA263317"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA266937"],"award-info":[{"award-number":["K08CA266937"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24AG070285"],"award-info":[{"award-number":["K24AG070285"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K24DA056837"],"award-info":[{"award-number":["K24DA056837"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM128691"],"award-info":[{"award-number":["R35GM128691"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer pain is a complex, multifactorial, and growing public health challenge affecting millions of Americans. Effective pain management is essential for comprehensive cancer care, influencing physical and mental health, quality of life, and functional ability. However, progress in cancer pain management is hindered by the complexity of the issue and a fragmented understanding of the myriad factors shaping the pain experience. Additionally, traditional pain terminology\u2014\u201cacute\u201d (&lt;6 months) and \u201cchronic\u201d pain (\u22656 months)\u2014offers limited utility in cancer contexts, highlighting the need for a more nuanced framework. To address this gap, we propose the 3P\u2010CP model, which conceptualizes cancer pain through three interconnected phases: predisposing factors that increase cancer pain risk, precipitating factors that trigger cancer pain onset, and perpetuating factors that sustain or exacerbate cancer pain over time. This model provides a structured approach to assess the dynamic nature of cancer pain across the entirety of the cancer trajectory. In this paper, key factors associated with each phase of the 3P\u2010CP model are outlined and their implications for research and clinical care explored. Aligning with the oncology field's shift toward precision medicine, the 3P\u2010CP model has the potential to guide comprehensive assessment, risk mitigation, prevention, and intervention strategies\u2014supporting efforts to deliver the right targeted and tailored treatments, to the right patients, at the right time.<\/jats:p>","DOI":"10.1002\/cncr.70080","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:01:52Z","timestamp":1757584912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The 3P\u2010CP model: Expanding our conceptualization of cancer\u00a0pain"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6993-1776","authenticated-orcid":false,"given":"Desiree R.","family":"Azizoddin","sequence":"first","affiliation":[{"name":"Department of Supportive Oncology Dana Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1034-1741","authenticated-orcid":false,"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Supportive Oncology Dana Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-2979","authenticated-orcid":false,"given":"Tamara J.","family":"Somers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Cancer Institute Duke University Health System  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Winger","sequence":"additional","affiliation":[{"name":"Pain Prevention and Treatment Research Program Department of Psychiatry and Behavioral Sciences Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan G.","family":"Dorsey","sequence":"additional","affiliation":[{"name":"Department of Pain &amp; Translational Symptom Science University of Maryland School of Nursing University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Orris","sequence":"additional","affiliation":[{"name":"Challenges in Managing and Preventing Pain (CHAMPP) Clinical Research Center Division of General Internal Medicine Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anaanya","family":"Nasta","sequence":"additional","affiliation":[{"name":"Challenges in Managing and Preventing Pain (CHAMPP) Clinical Research Center Division of General Internal Medicine Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Schenker","sequence":"additional","affiliation":[{"name":"Section of Palliative Care and Medical Ethics Division of General Internal Medicine Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Palliative Research Center (PaRC) University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica S.","family":"Merlin","sequence":"additional","affiliation":[{"name":"Challenges in Managing and Preventing Pain (CHAMPP) Clinical Research Center Division of General Internal Medicine Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-3711","authenticated-orcid":false,"given":"Heather S. L.","family":"Jim","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative, and Pain Medicine Brigham and Women\u2019s Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-0303","authenticated-orcid":false,"given":"Hailey W.","family":"Bulls","sequence":"additional","affiliation":[{"name":"Challenges in Managing and Preventing Pain (CHAMPP) Clinical Research Center Division of General Internal Medicine Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Section of Palliative Care and Medical Ethics Division of General Internal Medicine Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Palliative Research Center (PaRC) University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.52.4827"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/njh.0000000000000965"},{"key":"e_1_2_7_4_1","unstructured":"American Cancer Society.Cancer Facts & Figures 2025. Accessed March 7 2025.https:\/\/www.cancer.org\/cancer\u2010facts\u2010and\u2010statistics"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.68.5206"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae135"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0885\u20103924(02)00497\u20109"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.08.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0979"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/op.22.00142"},{"issue":"3","key":"e_1_2_7_11_1","first-page":"217","article-title":"The difference between acute and chronic pain","volume":"58","author":"Grichnik KP","year":"1991","journal-title":"Mt Sinai J Med"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.02.421"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.1030899"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040510"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.847460"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.133.4.581"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7510.238"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.01.004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2019.08.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0193\u2010953x(18)30532\u2010x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14081982"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16142571"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.02498"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002343"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.10.010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12052"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4300\/jgme\u2010d\u201022\u201000480.1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.11.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010020\u201009479\u20102"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/coc.0b013e3182a79009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010017\u20103824\u20103"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2019.04.011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105749"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2021.04.008"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010024\u201008314\u20108"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/ajp.0000000000000672"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001999"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5595"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.12.001"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463713484296"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.S55598"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1094903"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.03.023"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.10.013"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59071327"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2018.02.002"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.005"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33645"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.4825"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.37.0437"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010024\u201008307\u20107"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010021\u201006146\u20104"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz094"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909120905780"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5560"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/02692163211004216"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.03.002"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1124\/mi.10.3.7"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184472"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.01.026"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463714545136"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.09.012"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3338\u201007.2008"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3628"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.01399"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz011"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000653"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001540"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2813"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.01399"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnab039"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/ajp.0000000000000792"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095\u20103941.2021.0108"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12961"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.34.2816"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002880"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010016\u20103243\u2010x"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010195"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2016.0601"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.13401"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010018\u20100730\u20108"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.2196\/36889"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.029"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.32.31_suppl.197"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2011\/14\/145"},{"issue":"3","key":"e_1_2_7_86_1","first-page":"93","article-title":"Differentiating neuropathic pain, opioid\u2010induced hyperalgesia and opioid tolerance; considerations following a remarkable case","volume":"9","author":"Kenter EGH","year":"2010","journal-title":"Adv Palliat Med"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35299"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2022.0538"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/10499091231164634"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6308"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.22.00251"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.01.015"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33532"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2020.39.28_suppl.192"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.08.007"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153203"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.05.014"},{"key":"e_1_2_7_98_1","unstructured":"American Cancer Society.Cancer Treatment & Survivorship Facts & Figures 2022\u20102024.2022."},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.52.4629"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.106682"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2023.07.002"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211001850"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22080"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/pr9.0000000000000896"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2022.08.010"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnac163"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/nnr.0000000000000407"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.22200"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.70080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:58:34Z","timestamp":1773853114000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":107,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,9,15]]}},"alternative-id":["10.1002\/cncr.70080"],"URL":"https:\/\/doi.org\/10.1002\/cncr.70080","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,11]]},"assertion":[{"value":"2025-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70080"}}