{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:40:08Z","timestamp":1790653208942,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA252633"],"award-info":[{"award-number":["K08CA252633"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R25CA190169"],"award-info":[{"award-number":["R25CA190169"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R21NR019669"],"award-info":[{"award-number":["R21NR019669"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with advanced cancer receiving home health care experience elevated psychosocial and existential distress, yet few interventions address these concerns. This pilot randomized controlled trial examined the feasibility, acceptability, and preliminary efficacy of brief, nurse\u2010delivered, meaning\u2010centered psychotherapy in patients with advanced cancer compared with treatment as usual (TAU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Distressed patients (aged 18 years and older) were randomized 1:1 to receive either a three\u2010session Meaning\u2010Centered Psychotherapy for Hospitals, Hospice, and Home (MCP\u2010H;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a033) or TAU (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032). Feasibility was based on recruitment, retention, data completion, fidelity, and intervention engagement. Acceptability was based on patients\u2019 and nurses\u2019 ratings of MCP\u2010H satisfaction. Preliminary efficacy was determined by changes in scores from baseline (T1) to 6 weeks (T2) and 10 weeks (T3) in meaning, and secondary outcomes were assessed using between\u2010group analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010one patients enrolled. Feasibility was demonstrated by satisfactory recruitment (75% approach\u2010to\u2010consent rate; 92% enroll\u2010to\u2010randomize rate), retention (74% and 75% at T2 and T3, respectively), intervention engagement (94% completed 100% of the sessions), and treatment adherence (87% mean rating). Participants endorsed the intervention\u2019s acceptability (96% satisfied or very satisfied). MCP\u2010H participants experienced improvements in meaning using the Cohen's\u00a0d (d\u00a0=\u00a00.59 at T2; d\u00a0=\u00a00.39 at T3) and most other secondary psychosocial outcomes at 6 and 10 weeks compared with TAU participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MCP\u2010H is feasible and acceptable among patients with advanced cancer in home care. This intervention demonstrated promising evidence of clinical efficacy. A larger, fully powered randomized controlled trial is needed to test the efficacy of the intervention for patients, nurses, and health system outcomes against an active control group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70082","type":"journal-article","created":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T07:05:33Z","timestamp":1757833533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A pragmatic randomized controlled pilot trial of brief meaning\u2010centered psychotherapy in home care"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1093-7676","authenticated-orcid":false,"given":"Rebecca M.","family":"Saracino","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-2511","authenticated-orcid":false,"given":"Ellen Y.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Pessin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Onorato","sequence":"additional","affiliation":[{"name":"Center for Home Care Policy and Research Visiting Nurse Service Health  New York NewYork USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret V.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Center for Home Care Policy and Research Visiting Nurse Service Health  New York NewYork USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caraline","family":"Demirjian","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Schofield","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-2777","authenticated-orcid":false,"given":"Barry","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Department of Psychology Fordham University  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Breitbart","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison J.","family":"Applebaum","sequence":"additional","affiliation":[{"name":"Brookdale Department of Geriatrics and Palliative Medicine Icahn School of Medicine at Mount Sinai  New York New York 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