{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:29:17Z","timestamp":1792697357398,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depression has been identified as an adverse mental health outcome in women with breast cancer (BC). Depression was\u00a0investigated as a risk factor for poor survival in premenopausal women with hormone\u2010responsive early BC treated in the TEXT (Tamoxifen and Exemestane Trial) and SOFT (Suppression of Ovarian Function Trial) trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data used were from a subset of patients who participated in TEXT or SOFT and completed the Center of Epidemiologic Studies\u2010Depression scale. Associations between baseline depression\u2010score categories and baseline characteristics were assessed using the Cochran\u2013Mantel\u2013Haenszel test controlling for antidepressant use. Multivariable proportional hazards regression models were used to test the association between baseline depression and disease\u2010free survival (DFS) and overall survival (OS). Regression models were adjusted for factors known to be associated with outcomes, baseline antidepressant use, and early treatment cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty percent (2287 of 5738) of the women enrolled in the SOFT and TEXT trials were included in this analysis (SOFT,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01259; TEXT,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01028). Twenty\u2010seven percent of women reported mild\u2010to\u2010moderate or severe depression at baseline. Race (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001), body mass index (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.02), family history (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.02), and performance status (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=.007) were significantly associated with the severity of depression. Relative to the no\u2010symptomatology group, the hazard ratios (overall\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.04) for DFS were 1.34 (95% confidence interval [CI], 1.03\u20131.76) for women with mild\u2010to\u2010moderate depression and 1.34 (95% CI, 0.96\u20131.87) for those with severe depression. Relative to the no\u2010symptomatology group, the hazard ratios (overall\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008) for OS were 1.68 for mild\u2010to\u2010moderate depression (95% CI, 1.15\u20132.44) and 1.67 for those with severe depression (95% CI, 1.05\u20132.66).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In premenopausal women with hormone\u2010responsive early BC, depression at baseline is a risk factor for poorer DFS and OFS. Further investigation of the underlying interactive processes is needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Clinicaltrials.gov NCT00066703 (SOFT) and NCT00066690 (TEXT).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70094","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:54:01Z","timestamp":1758650041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic value of patient\u2010reported depression in women with hormone\u2010responsive early breast cancer in TEXT and SOFT"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-1197","authenticated-orcid":false,"given":"Karin","family":"Ribi","sequence":"first","affiliation":[{"name":"International Breast Cancer Study Group (IBCSG) a division of ETOP (European Thoracic Oncology Platform) IBCSG Partners Foundation  Bern Switzerland"},{"name":"Careum School of Health Part of the Kalaidos University of Applied Sciences  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard F.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gini F.","family":"Fleming","sequence":"additional","affiliation":[{"name":"The University of Chicago Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Walley","sequence":"additional","affiliation":[{"name":"University of Calgary and Canadian Cancer Trials Group  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prudence A.","family":"Francis","sequence":"additional","affiliation":[{"name":"The Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Center, St Vincent\u2019s Hospital, University of Melbourne  Melbourne Victoria Australia"},{"name":"Breast Cancer Trials Australia and New Zealand, University of Newcastle  Callaghan Newcastle Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehtesham","family":"Abdi","sequence":"additional","affiliation":[{"name":"Breast Cancer Trials Australia and New Zealand The Tweed Hospital Tweed Heads Griffith University Gold Coast  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold J.","family":"Burstein","sequence":"additional","affiliation":[{"name":"Susan F. Smith Center for Women\u2019s Cancers Dana\u2010Farber Cancer Institute, Harvard Medical School  Boston Massachusetts USA"},{"name":"Alliance for Clinical Trials in Oncology  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit L.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Northwell Health Division of Medical Oncology and Hematology Zucker School of Medicine at Hofstra University  Lake Success New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen K. L.","family":"Chia","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology The University of British Columbia and British Columbia Cancer Agency  Vancouver British Columbia Canada"},{"name":"Canadian Cancer Trials Group  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaker R.","family":"Dakhil","sequence":"additional","affiliation":[{"name":"Wichita National Cancer Institute Community Oncology Research Program Via Christi Regional Medical Center and Cancer Center of Kansas  Wichita Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center University of Washington Seattle  Seattle Washington USA"},{"name":"Eastern Cooperative Oncology Group\u2013American College of Radiology Imaging Network Cancer Research Group  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Della\u2010Fiorentina","sequence":"additional","affiliation":[{"name":"Macarthur Cancer Center Campbelltown Hospital  Campbelltown New South Wales Australia"},{"name":"Breast Cancer Trials Australia and New Zealand  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley E.","family":"Frith","sequence":"additional","affiliation":[{"name":"Division of Oncology John T. Milliken Department of Medicine Washington University School of Medicine  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellis","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Medicine Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Lupichuk","sequence":"additional","affiliation":[{"name":"Arthur J.E.Child Comprehensive Cancer Center  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Canadian Cancer Trials Group  Kingston Ontario Canada"},{"name":"Odette Cancer Research Program Sunnybrook Health Sciences Center Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Salim","sequence":"additional","affiliation":[{"name":"Allen Blair Cancer Center  Regina Saskachewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered","family":"Stearns","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Department of Medicine Weill Cornell Medical School  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Stewart","sequence":"additional","affiliation":[{"name":"Breast Cancer Trials Australia and New Zealand  Newcastle New South Wales Australia"},{"name":"Austin Hospital  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Valero","sequence":"additional","affiliation":[{"name":"Breast Medical Oncology Department The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"van der Westhuizen","sequence":"additional","affiliation":[{"name":"Breast Cancer Trials Australia and New Zealand The Tweed Hospital Tweed Heads Griffith University Gold Coast  Newcastle New South Wales Australia"},{"name":"Calvary Mater Newcastle Hospital  Waratah New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Pagani","sequence":"additional","affiliation":[{"name":"Geneva University Hospitals  Geneva Switzerland"},{"name":"Lugano University  Lugano Switzerland"},{"name":"Swiss Group for Clinical Cancer Research  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherene","family":"Loi","sequence":"additional","affiliation":[{"name":"International Breast Cancer Study Group (IBCSG) a division of ETOP (European Thoracic Oncology Platform) IBCSG Partners Foundation  Bern Switzerland"},{"name":"The Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Center, St Vincent\u2019s Hospital, University of Melbourne  Melbourne Victoria Australia"},{"name":"Division of Cancer Research Peter MacCallum Cancer Center  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Colleoni","sequence":"additional","affiliation":[{"name":"Division of Medical Senology European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Gelber","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Department of Data Science IBCSG Statistical Center Dana\u2010Farber Cancer Institute, Harvard Medical School  Boston Massachusetts USA"},{"name":"Frontier Science Foundation  Boston Massachusetts USA"},{"name":"Harvard T.H. 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