{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:01:45Z","timestamp":1788307305839,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>OB756 is a novel oral selective JAK2 inhibitor targeting the JAK\u2010STAT pathway. This study assessed its safety and efficacy in patients with essential thrombocythemia (ET) who were resistant to or intolerant of hydroxyurea or intolerant of interferon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This phase 2, single\u2010arm, open\u2010label, multicenter clinical trial evaluated the efficacy and safety of OB756 in patients with ET who were intolerant of or resistant to hydroxyurea, or intolerant of interferon. The primary end point was the complete hematologic response (CHR) rate at week 24, whereas secondary end points included hematologic response (HR), the proportion of patients with \u226535% spleen volume reduction at week 24, molecular response, and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 24, the CHR was 22% (11 of 50) based on intention\u2010to\u2010treat analysis. Among evaluable patients, the HR rate reached 65.6% at week 24. At week 24, 94.7% of patients (36 of 38) experienced spleen volume reduction, with 50.0% achieving \u226535% reduction. Additionally, 74.2% of patients (23 of 31) had a \u226550% reduction in myeloproliferative neoplasm symptom assessment form total symptom score. Among evaluable patients, 84.7% (11 of 13) had a reduction in\n                      <jats:italic>JAK2\u2010V617F<\/jats:italic>\n                      allele burden post\u2010treatment. In terms of safety, most treatment\u2010related adverse events (TEAEs) were grade 1\u20132. Grade \u22653 hematologic TEAEs included anemia (10%) and neutropenia (6%). The incidence of grade \u22653 infections was 16% and grade \u22653 thrombotic events was 2%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, OB756 was well\u2010tolerated and demonstrated acceptable efficacy, offering a promising therapeutic option for ET patients who are resistant to or intolerant of hydroxyurea or intolerant of interferon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70101","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:17:49Z","timestamp":1759958269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of OB756 (a novel selective JAK2 inhibitor) for essential thrombocythemia in patients intolerant of or resistant to hydroxyurea or intolerant of interferon: A phase 2, open\u2010label, multicenter study"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-8636","authenticated-orcid":false,"given":"Jian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Department of Hematology The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiejun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Hospital of Harbin  Harbin Heilongjiang 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