{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:54:38Z","timestamp":1793501678744,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Risk\u2010reducing surgeries are the most effective strategies for cancer prevention in patients with germline pathogenic variants in the\n                      <jats:italic>BRCA1<\/jats:italic>\n                      \/\n                      <jats:italic>BRCA2<\/jats:italic>\n                      genes; these surgeries are associated with early menopause, loss of childbearing potential, and cosmetic effects. The authors assessed women's preferences for tradeoffs related to risk\u2010reducing surgical decision making.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Carriers of pathogenic mutations in\n                      <jats:italic>BRCA1\/BRCA2<\/jats:italic>\n                      aged 25\u201350 years without a personal history of breast, ovarian, peritoneal, or tubal cancer were recruited to complete one of four discrete choice surveys based on their age (younger than 40 years or 40 years and older) and\n                      <jats:italic>BRCA<\/jats:italic>\n                      mutation status (BRCA1 or BRCA2). Participants responded to a series of choices between a\n                      <jats:italic>do\u2010nothing<\/jats:italic>\n                      strategy and two profiles representing various effects of surgical options on menopause, childbearing potential (those younger than 40 years only), breast appearance, and 10\u2010year and lifetime risks of breast and ovarian cancer. A conditional logit model was used to quantify participants' choices as a function of surgical options and outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 298 participants completed the survey. Each cohort younger than &lt;40 years more frequently chose profiles representing risk\u2010reducing salpingo\u2010oophorectomy (RRSO) at age 40 versus 30 years. The cohort aged 40 years and older with\n                      <jats:italic>BRCA1<\/jats:italic>\n                      mutations favored RRSO at age 40 years but with a 56.6% choice probability of delayed RRSO after ages 35\u201340 years, as recommended by National Comprehensive Cancer Network guidelines. The cohort aged 40 and older with\n                      <jats:italic>BRCA2<\/jats:italic>\n                      mutations favored RRSO at age 40, 45, or 50 years fairly equally, with a 33.0% choice probability of guideline\u2010nonconcordant RRSO timing. All cohorts favored mastectomy at younger ages and with reconstruction versus no mastectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate the heterogeneity of preferences and support individualized discussion of treatment goals relating to risk\u2010reducing surgical planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70148","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:29:21Z","timestamp":1763141361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preferences of BRCA mutation carriers for attributes of risk\u2010reducing surgical options for breast and ovarian cancer"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-9875","authenticated-orcid":false,"given":"Katherine C.","family":"Fitch","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-6578","authenticated-orcid":false,"given":"Jui\u2010Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-9178","authenticated-orcid":false,"given":"Emma S.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Monuszko","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine N.","family":"Penvose","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Friedman","sequence":"additional","affiliation":[{"name":"Facing Our Risk of Cancer Empowered, Inc. 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