{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:18:44Z","timestamp":1779322724556,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic myelomonocytic leukemia (CMML) is largely a disease of individuals older than 50 years; its occurrence in patients aged 50 years and younger is rare. The authors sought to characterize the clinicopathologic features and genetic profile of young\u2010onset (age 50 years and younger) CMML (y\u2010CMML) compared with older onset (older than 50 years) CMML (o\u2010CMML).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors conducted a multi\u2010institutional study of 32 patients with y\u2010CMML and 119 patients with o\u2010CMML, analyzing clinical, morphologic, cytogenetic, and molecular data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients who had y\u2010CMML frequently presented with splenomegaly (59% vs. 11%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and hepatomegaly (25% vs. 2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) compared with those who had o\u2010CMML. Although the overall incidence of cytogenetic abnormalities was similar, patients who had y\u2010CMML exhibited distinct mutational patterns.\n                      <jats:italic>PTPN11<\/jats:italic>\n                      mutations were significantly more common in y\u2010CMML (13% vs. 3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.034) than in o\u2010CMML, whereas\n                      <jats:italic>TET2<\/jats:italic>\n                      (6% vs. 57%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and\n                      <jats:italic>SRSF2<\/jats:italic>\n                      (16% vs. 46%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002) mutations were significantly less frequent. In addition, multi\u2010hit\n                      <jats:italic>TET2<\/jats:italic>\n                      (6% vs. 34%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002) and\n                      <jats:italic>TET2\u2010SRSF2<\/jats:italic>\n                      (3% vs. 29%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003) co\u2010mutations were rare in y\u2010CMML. However, the molecular differences did not affect the CMML\u2010specific risk\u2010stratification categories because the clinical outcomes, including overall survival and leukemia\u2010free survival, did not differ between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CMML in patients aged 50 years and younger is rare and presents with unique clinical and mutational features, suggesting a distinct pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70176","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:05:27Z","timestamp":1763132727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic myelomonocytic leukemia in the young (aged 50 years and younger): Divergent clinical and molecular characteristics from the elderly"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6822-7880","authenticated-orcid":false,"given":"Chi Young","family":"Ok","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuya","family":"Natu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parnaz","family":"Daneshpajouhnejad","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamiaa A.","family":"Fathalla","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Clinical Pathology National Cancer Institute, Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Symes","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Barone","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medical College  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Shestakova","sequence":"additional","affiliation":[{"name":"Department of Pathology Associated Regional and University Pathologist (ARUP) Laboratories University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn K.","family":"Foucar","sequence":"additional","affiliation":[{"name":"Department of Pathology University of New Mexico Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Bueso\u2010Ramos","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-5176","authenticated-orcid":false,"given":"Guillermo","family":"Montalban\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio","family":"Orazi","sequence":"additional","affiliation":[{"name":"Department of Pathology Texas Tech Health Sciences Center  El Paso Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hasserjian","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital  Massachusetts Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"A. 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