{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:27Z","timestamp":1786977507759,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The systemic study of thymic mucosa\u2010associated lymphoid tissue (MALT) lymphoma remains lacking. The objective of this study was to characterize the clinical features and outcomes of patients with thymic MALT lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors conducted a retrospective analysis of patients with thymic MALT lymphoma who were diagnosed at multiple medical centers in China from 2011 to 2024. Clinical, laboratory, therapeutic, and survival data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 82 patients were included. The median age of the cohort was 47 years with a female predominance (female\/male ratio\u00a0=\u00a05.3:1.0). Eighty\u2010two percent of patients presented with limited stage disease. Forty\u2010one patients had a definitive diagnosis of autoimmune disease, with Sjogren's syndrome being the most common (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037). Antinuclear antibodies were positive in 42 of 44 (95%) of examined patients. Management strategies included watch and wait (2%), local therapy alone (surgery, radiotherapy, or both; 71%), a combination of local and systemic therapy (26%), or systemic therapy alone (1%). With a median follow\u2010up of 2.7 years, the 2\u2010year progression\u2010free and overall survival rates for the entire cohort were 98.6% (95% confidence interval, 95.8%\u2013100.0%) and 100% (95% confidence interval, 100.0%\u2013100.0%), respectively. Patients treated with local therapy alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a058) and those who received local and systemic therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021) had similar progression\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.530). Patients who underwent surgery alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a053) had a 2\u2010year progression\u2010free survival rate of 100% (95% confidence interval, 100.0%\u2013100.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with thymic MALT lymphoma have an excellent prognosis. Sjogren\u2019s syndrome is closely associated with thymic MALT lymphoma. Routine screening for autoimmune disorders and surgical resection are recommended for patients who have newly diagnosed thymic MALT lymphomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70183","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T15:48:22Z","timestamp":1763826502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics and survival outcomes of thymic mucosa\u2010associated lymphoid tissue lymphoma: A multicenter analysis of 82 patients"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-3332","authenticated-orcid":false,"given":"Wenyu","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Nantong University  Nantong 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Hematology The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-4987","authenticated-orcid":false,"given":"Lei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology Lymphoma Center Jiangsu Province Hospital The First Affiliated Hospital of Nanjing Medical University  Nanjing 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