{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:44:42Z","timestamp":1785498282795,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1CA233080"],"award-info":[{"award-number":["UM1CA233080"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Electronic patient\u2010reported outcomes (ePROs) mitigate symptom burden among cancer patients. This study hypothesized that two single\u2010item quality of life measures, overall well\u2010being (OWB) and physical function (PFN), could provide distinct information that augment ePROs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>eSyM, an electronic symptom management program, was deployed across six institutions for patients receiving chemotherapy or surgery for a suspected or confirmed thoracic, gastrointestinal, or gynecologic malignancy. eSyM prompts patients one to three times weekly to complete a 12\u2010item symptom questionnaire and two pictogram questions assessing OWB and PFN. The study identified characteristics associated with OWB\/PFN; described correlations between OWB\/PFN, severe symptoms, and total symptom burden; and characterized relationships between OWB\/PFN and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From September 2019 to February 2024, 10,176 patients (3669 chemotherapy and 6507 surgery) submitted 78,433 questionnaires. The plurality reported mild impairment for OWB (chemotherapy, 41%; surgery, 45%) and PFN (chemotherapy, 43%; surgery, 39%). OWB and PFN were moderately correlated with each other (chemotherapy, 0.62; surgery, 0.58); with total symptom burden (chemotherapy: OWB 0.57, PFN 0.52; surgery: OWB 0.63, PFN 0.53); and with pain, fatigue, and decreased appetite (0.39\u20130.61). OWB and PFN varied by employment status and institution, and were associated with emergency department visits, admissions, and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Self\u2010reported OWB and PFN were moderately correlated with common symptoms, offered discriminant and face validity, and were associated with clinical outcomes. These measures supplemented information from a multi\u2010item questionnaire and may guide management for cancer patients by contextualizing symptom reports and functioning as a brief screen to identify patients at risk for moderate\u2013severe symptoms or other serious outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70185","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:19:24Z","timestamp":1764260364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Self\u2010reported overall well\u2010being and physical function among chemotherapy and surgery patients across six institutions"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-3510","authenticated-orcid":false,"given":"Michael J.","family":"Hassett","sequence":"first","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-0923","authenticated-orcid":false,"given":"Christine M.","family":"Cronin","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C.","family":"Tramontano","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Uno","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Paudel","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica J.","family":"Bian","sequence":"additional","affiliation":[{"name":"Maine Medical Center  Portland Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don S.","family":"Dizon","sequence":"additional","affiliation":[{"name":"Tufts Medicine &amp; Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Hazard\u2010Jenkins","sequence":"additional","affiliation":[{"name":"West Virginia University Cancer Center  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond U.","family":"Osarogiagbon","sequence":"additional","affiliation":[{"name":"Baptist Health System  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deb","family":"Schrag","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7156"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.0830"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01038"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.23.00182"},{"key":"e_1_2_9_6_1","unstructured":"National Cancer Institute.Improving the Management of symPtoms during And following Cancer Treatment (IMPACT). Accessed January 15 2024.https:\/\/healthcaredelivery.cancer.gov\/impact\/"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.21.00137"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010022\u201006435\u20101"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.11.3662"},{"key":"e_1_2_9_10_1","unstructured":"National Cancer Institute.Patient\u2010reported outcomes version of the Common Terminology Criteria for Adverse Events (PRO\u2010CTCAE). Accessed January 15 2024.https:\/\/healthcaredelivery.cancer.gov\/pro\u2010ctcae\/"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae049"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010publhealth\u2010052120\u2010012811"},{"key":"e_1_2_9_13_1","unstructured":"RAND Health.36\u2010Item Short Form Survey (SF\u201036). Accessed January 15 2024.https:\/\/www.rand.org\/health\/surveys\/mos\/36\u2010item\u2010short\u2010form.html"},{"key":"e_1_2_9_14_1","unstructured":"HealthMeasures.Intro to PROMIS. Accessed January 15 2024.https:\/\/www.healthmeasures.net\/explore\u2010measurement\u2010systems\/promis\/intro\u2010to\u2010promis"},{"key":"e_1_2_9_15_1","unstructured":"EUROQOL.EUROQOL instruments. Accessed January 15 2024.https:\/\/euroqol.org\/information\u2010and\u2010support\/euroqol\u2010instruments\/eq\u20105d\u20103l\/"},{"key":"e_1_2_9_16_1","unstructured":"FACIT.FACT\u2010G. Accessed January 15 2024.https:\/\/www.facit.org\/measures\/fact\u2010g"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20101\u201054"},{"key":"e_1_2_9_18_1","unstructured":"EORTC.Quality of Life Group. 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