{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:48:13Z","timestamp":1785437293373,"version":"3.56.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA186646"],"award-info":[{"award-number":["R01 CA186646"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA300518"],"award-info":[{"award-number":["R01 CA300518"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA249955"],"award-info":[{"award-number":["U01 CA249955"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["IRG60\u2010001\u201047"],"award-info":[{"award-number":["IRG60\u2010001\u201047"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI007051"],"award-info":[{"award-number":["T32 AI007051"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Standardized incidence rates of multiple myeloma (MM) are higher among males than females, suggesting that male sex is an important risk factor for MM, which may affect disease etiology, pathogenesis, and clinical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The association of sex with the prevalence of clinical features and chromosomal abnormalities was evaluated among 850 patients with newly diagnosed MM enrolled in the Integrative Molecular And Genetic Epidemiology (IMAGE). Risk estimates were calculated using prevalence odds ratios (OR) and corresponding 95% CIs from logistic regression adjusted for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Male patients with newly diagnosed MM by comparison with females, were more likely to have International Staging System stage III disease (odds ratio [OR]\u00a0=\u00a02.05; 95% CI, 1.22\u20133.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.007), high serum monoclonal protein (\u22653 g\/dL; OR\u00a0=\u00a01.72; 95% CI, 1.15\u20132.56;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008), \u03ba light chain disease (OR\u00a0=\u00a01.60; 95% CI, 1.11\u20132.30;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01), and more end\u2010organ damage (OR\u00a0=\u00a01.24; 95% CI, 1.02\u20131.50;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.03) including impaired renal function (OR\u00a0=\u00a01.71; 95% CI, 1.12\u20132.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01) and lytic lesions (OR\u00a0=\u00a01.97; 95% CI, 1.01\u20133.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.05) and were less likely to have osteopenia (OR\u00a0=\u00a00.59; 95% CI, 0.36\u20130.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.04) and light chain only disease (OR\u00a0=\u00a00.63; 95% CI, 0.41\u20130.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.03) after adjusting for race, age, body mass index, education, income, smoking, and alcohol use. Significant interactions of age on the association of male sex with the prevalence of involved to uninvolved free light chain ratio \u2265100 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01) and any copy number abnormality (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.04) were also observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These novel findings suggest that male patients with newly diagnosed MM have a greater tumor burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70192","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:01:23Z","timestamp":1768204883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sex differences in the clinical presentation of patients with newly diagnosed multiple myeloma"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-4006","authenticated-orcid":false,"given":"Krystle L.","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Pathology Heersink School of Medicine, University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Pathology Heersink School of Medicine, University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith C.","family":"Wessel","sequence":"additional","affiliation":[{"name":"Department of Pathology Heersink School of Medicine, University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayatri","family":"Ravi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Department of Medicine Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"O\u2019Neal Comprehensive Cancer Center University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith E.","family":"Davies","sequence":"additional","affiliation":[{"name":"Perlmutter Comprehensive Cancer Center New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth J.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Perlmutter Comprehensive Cancer Center New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology Heersink School of Medicine, University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"O\u2019Neal Comprehensive Cancer Center University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(14)70442\u20105"},{"key":"e_1_2_11_4_1","volume-title":"Cancer Epidemiology and Prevention","author":"Purdue 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