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This study describes cancer incidence (2014\u20132018), trends (1998\u20132018), and stage of diagnosis across the Navajo Nation, one of the largest sovereign tribal nations worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cases from six Arizona, New Mexico, and Utah counties covering most of the Navajo Nation were identified by population\u2010based cancer registries and linked with Indian Health Services patient registrations. Cancer incidence and stage at diagnosis were compared between Navajo and non\u2010Hispanic White persons in the same counties. Trends from 1998 through 2018 were analyzed using Joinpoint regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Navajo people had significantly higher incidence than non\u2010Hispanic White people of gallbladder (incidence rate ratio [RR]\u00a0=\u00a06.25), stomach (RR\u00a0=\u00a03.19), kidney (RR\u00a0=\u00a01.89), myeloma (RR\u00a0=\u00a01.80), and liver cancers (RR\u00a0=\u00a01.79) and a lower incidence of cancers of the lung (RR\u00a0=\u00a00.16), female breast (RR\u00a0=\u00a00.49), leukemia (RR\u00a0=\u00a00.49), prostate (RR\u00a0=\u00a00.62), pancreas (RR\u00a0=\u00a00.79), and non\u2010Hodgkin lymphoma (RR\u00a0=\u00a00.79). Diagnostic stage was not different for breast, cervical, and colorectal cancers, but two thirds of patients with cervical and colorectal cancer were diagnosed in later\/unknown stages. Although all\u2010site cancer rates did not change significantly from 1998 through 2018 among Navajo people, a significant decrease was found from 2010 through 2018 (\u20132.1% annual percentage change,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Navajo people experience a higher incidence of kidney, stomach, liver, myeloma, and gallbladder cancers and a lower incidence of cancers of the breast, prostate, lung, non\u2010Hodgkin lymphoma, and leukemia. Tailored and targeted prevention efforts may help reduce cancer disparities in the Navajo Nation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70202","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:45:02Z","timestamp":1765561502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cancer incidence, stage at diagnosis, and trends across the Navajo Nation, 2014\u20132018"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5682-4012","authenticated-orcid":false,"given":"Del","family":"Yazzie","sequence":"first","affiliation":[{"name":"Navajo Epidemiology Center Navajo Department of Health  Window Rock Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dornell","family":"Pete","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Briscoe","sequence":"additional","affiliation":[{"name":"Navajo Cancer Prevention Program Navajo Department of Health  Window Rock Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Jim","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Meisner","sequence":"additional","affiliation":[{"name":"New Mexico Tumor Registry University of New Mexico Comprehensive Cancer Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Wiggins","sequence":"additional","affiliation":[{"name":"New Mexico Tumor Registry University of New Mexico Comprehensive Cancer Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Doyle","sequence":"additional","affiliation":[{"name":"Arizona Department of Health Services Arizona Cancer Registry  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Yee","sequence":"additional","affiliation":[{"name":"Arizona Department of Health Services Arizona Cancer Registry  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1374-7431","authenticated-orcid":false,"given":"Carol","family":"Goldtooth","sequence":"additional","affiliation":[{"name":"Northern Arizona University  Flagstaff Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla R.","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Northern Arizona University  Flagstaff Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chesleigh Nicole","family":"Keene","sequence":"additional","affiliation":[{"name":"Kauffman and Associates Incorporated  Spokane Washingtom USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Smith","sequence":"additional","affiliation":[{"name":"Northern Arizona University  Flagstaff Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Sehn","sequence":"additional","affiliation":[{"name":"Community Outreach and Patient Empowerment, Inc.  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