{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:28:57Z","timestamp":1786796937853,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Isolated chromosome 5\/5q losses (\u20135\/5q) without\n TP53<\/jats:italic>\n mutations are associated with favorable outcomes in myeloid neoplasms (MN) with <5% blasts. However, the clinical implication of concurrent \u22125\/5q and\n TP53<\/jats:italic>\n aberrations in MN with \u22655% blasts is poorly understood.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with\n TP53<\/jats:italic>\n \u2010mutated MN carrying \u22655% blasts assessing the prognostic impact of \u20105\/5q on 24\u2010month overall survival (OS24) were examined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 587 patients, 515 (88%) exhibited \u22125\/5q overwhelmingly in the context of a complex karyotype (98.3% vs. 61.1% complex karyotype without \u22125\/5q;\n p\u00a0<<\/jats:italic>\n \u00a0.0001) and multihit\n TP53<\/jats:italic>\n allelic state (88.3% vs. 56.9%;\n p\u00a0<<\/jats:italic>\n \u00a0.0001). Proportions of patients with blasts \u226520% were comparable between groups with and without \u22125\/5q;\n p\u00a0=<\/jats:italic>\n \u00a00.26. Notably, patients with \u22125\/5q exhibited significantly fewer coalterations;\n p\u00a0<<\/jats:italic>\n \u00a0.0001. Looking at outcomes, presence of \u22125\/5q was associated with shorter median 24\u2010month overall survival (7.8 months vs. 11.2 months;\n p<\/jats:italic>\n \n Log\u2010rank<\/jats:italic>\n <\/jats:sub>\n \u00a0=\u00a0.012), an effect restricted to subgroups with blasts <20% (\n p\u00a0=<\/jats:italic>\n \u00a0.039;\n N\u00a0=<\/jats:italic>\n \u00a0163), absent \u22127\/7q (\n p\u00a0=<\/jats:italic>\n \u00a0.007;\n N\u00a0=<\/jats:italic>\n \u00a0225), or WHO5\u2010defined single hit allelic state (\n p\u00a0=<\/jats:italic>\n \u00a00.030;\n N\u00a0=<\/jats:italic>\n \u00a091). Importantly, \u22125\/5q retained independent adverse prognostic significance regardless of\n TP53<\/jats:italic>\n allelic state in a multivariable model. Furthermore, among the subset of 75 (13%) patients undergoing allogeneic stem cell transplantation, \u22125\/5q predicted significantly shorter median 5\u2010year posttransplant survival (16.2 months vs. median not reached;\n p<\/jats:italic>\n \n Log\u2010rank<\/jats:italic>\n <\/jats:sub>\n \u00a0=\u00a0.009).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These findings emphasize the independent prognostic relevance of chromosome 5\/5q losses underscoring the clinical relevance of cytogenetic testing for \u22125\/5q even in this high\u2010risk cohort.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cncr.70210","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T17:30:28Z","timestamp":1766165428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of chromosome 5 aberrations in\n TP53<\/i>\n mutated myeloid neoplasms with \u22655% blasts: An International\n TP53<\/i>\n Investigators Network (iTiN) study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8718-4352","authenticated-orcid":false,"given":"Irfan","family":"Yasin","sequence":"first","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stengel","sequence":"additional","affiliation":[{"name":"Munich Leukemia Laboratory Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Shao","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology), Medicine (Hematology Oncology) H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Pathology (Molecular Pathology) Endeavor Health Northshore Hospital Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily F.","family":"Mason","sequence":"additional","affiliation":[{"name":"Pathology, Microbiology, and Immunology (Hematopathology) Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-506X","authenticated-orcid":false,"given":"Pranav P.","family":"Patwardhan","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology) University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael G.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology) Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology) Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedar V.","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology) Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Pandiri","sequence":"additional","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology & Children's Hospital of Colorado) UCHealth University of Colorado Hospital Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Sojitra","sequence":"additional","affiliation":[{"name":"Pathology Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Tariq","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology) Northwestern Memorial Hospital Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenggang","family":"Pan","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology & Children's Hospital of Colorado) UCHealth University of Colorado Hospital Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Wiredja","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology & Children's Hospital of Colorado) UCHealth University of Colorado Hospital Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Y.","family":"Tjota","sequence":"additional","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Segal","sequence":"additional","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Program (Laboratory Hematology) University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Sallman","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology), Medicine (Hematology Oncology) H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Arber","sequence":"additional","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-3821","authenticated-orcid":false,"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[{"name":"Medicine (Division of Hematology) Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-918X","authenticated-orcid":false,"given":"Talha","family":"Badar","sequence":"additional","affiliation":[{"name":"Medicine (Hematology\u2010 Oncology) Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamarija M.","family":"Perry","sequence":"additional","affiliation":[{"name":"Pathology (Hematopathology) University of Michigan Ann Arbor Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Haferlach","sequence":"additional","affiliation":[{"name":"Munich Leukemia Laboratory Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Lager","sequence":"additional","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-2608","authenticated-orcid":false,"given":"Girish","family":"Venkataraman","sequence":"additional","affiliation":[{"name":"Pathology (Hematology\/Oncology & Hematopathology & Genomic Pathology & Cytogenetics), Medicine (Hematology\/Oncology) The University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001613\u20101"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.31.8576"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12203"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2022.01.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024023840"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp\u20102024\u2010209954"},{"key":"e_1_2_10_8_1","volume-title":"The International Consensus Classification of Myeloid and Lymphoid Neoplasms","author":"Arber 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