{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:36:25Z","timestamp":1793637385413,"version":"4.5.1"},"reference-count":36,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medications such as proton pump inhibitors (PPIs), antihistamines, and nonsteroidal anti\u2010inflammatory drugs have been linked to immune checkpoint inhibitor (ICI) efficacy in patients with non\u2013small cell lung cancer (NSCLC), but these associations may reflect unmeasured confounding rather than true pharmacologic effects. This study evaluated whether commonly prescribed medications influence ICI outcomes, using a national patient sample and a negative control cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The authors identified Veterans Health Administration (VHA) patients with stage IV NSCLC treated with first\u2010 or second\u2010line ICI therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03739) or chemotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06585) from 2005 to 2023. Baseline use of 20 common medication classes and an immunomodulatory drug score were assessed. Propensity\u2010weighted Cox regression evaluated associations between each medication class and overall survival (OS) or time\u2010to\u2010next treatment (TTNT) in the ICI group. For any medication with a nominally significant association (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05), the same analysis was repeated in the chemotherapy group to test for nonspecific effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After propensity weighting, 14 of 20 medication classes showed no association with OS or TTNT in the ICI cohort. Loop diuretics, anticoagulants, opioids, penicillin antibiotics, and fluoroquinolone antibiotics were associated with worse outcomes, but similar effects were seen in the chemotherapy group. A higher immunomodulatory drug score was also associated with inferior outcomes among ICI patients, but this association was likewise present in the chemotherapy cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, commonly prescribed medications did not appear to alter ICI efficacy in stage IV NSCLC. Prior associations reported in the literature may be attributable to unmeasured confounding rather than true drug\u2013immunotherapy interactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70222","type":"journal-article","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:00:52Z","timestamp":1765702852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of common medications on the efficacy of immune checkpoint inhibitors"],"prefix":"10.1002","volume":"131","author":[{"given":"Daria","family":"Brinzevich","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Falvello","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadiq S.","family":"Rehmani","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth W.","family":"Strohbehn","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Veterans Affairs Center for Clinical Management Research  Ann Arbor Michigan USA"},{"name":"Division of Oncology LTC Charles S. 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Kettles VA Medical Center  Ann Arbor Michigan USA"},{"name":"Rogel Cancer Center Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-7669","authenticated-orcid":false,"given":"Michael P.","family":"Dykstra","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Veterans Affairs Ann Arbor Healthcare System  Ann Arbor Michigan USA"},{"name":"Department of Radiation Oncology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4003-8535","authenticated-orcid":false,"given":"Luke M.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Veterans Affairs Ann Arbor Healthcare System  Ann Arbor Michigan USA"},{"name":"Department of Radiation Oncology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Veterans Affairs Ann Arbor Healthcare System  Ann Arbor Michigan USA"},{"name":"Department of Biostatistics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-7118","authenticated-orcid":false,"given":"Michael D.","family":"Green","sequence":"additional","affiliation":[{"name":"Anchorage Radiation Oncology Center  Anchorage Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-8381","authenticated-orcid":false,"given":"Alex 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