{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:01:14Z","timestamp":1777946474320,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2505800"],"award-info":[{"award-number":["2022YFC2505800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of magnetic resonance (MR)\u2010guided split\u2010course hypo\u2010fractionated radiotherapy (hypo\u2010RT) with concurrent chemotherapy followed by consolidative immunotherapy (CIT) in locally advanced non\u2013small cell lung cancer (LA\u2010NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this phase 2 trial, patients with unresectable stage IIIA\u2013C NSCLC (18\u201375 years old, Eastern Cooperative Oncology Group 0\u20131) received MR\u2010guided split\u2010course hypo\u2010RT (30 Gy in six fractions, repeated after 4 weeks for a total of 60 Gy) with concurrent weekly docetaxel (25 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and cisplatin (25 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). The primary end point was progression\u2010free survival (PFS); secondary end points included overall survival (OS), objective response rate (ORR), and toxicities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between July 2020 and January 2023, 104 patients were enrolled with a median follow\u2010up of 34.4 months. Split\u2010course hypo\u2010concurrent chemoradiotherapy (CCRT) was completed in 101 (97.1%) patients, and 74 (71.2%) received CIT. The median PFS was 27.5 months (95% confidence interval [CI], 18.9\u201336.0 months), and the 1\u2010 and 2\u2010year PFS rates were 76.9% (95% CI, 69.2%\u201385.5%) and 54.7% (95% CI, 45.9%\u201365.1%), respectively. The 1\u2010 and 2\u2010year OS were 87.5% (95% CI, 81.4%\u201394.1%) and 65.3% (95% CI, 56.8%\u201375.2%), respectively. The most common grade 3\u20134 adverse event was lymphopenia (35.6%). Grade 2\u20133 pneumonitis was observed in eight patients (7.7%) during hypo\u2010CCRT and in seven patients (6.7%) during CIT. Grade 3 esophagitis occurred in three patients (2.8%), and one grade 5 hemoptysis was reported (0.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The MR\u2010guided split\u2010course hypo\u2010CCRT delivered at 5 Gy per fraction to a total dose of 60 Gy followed by CIT yielded encouraging survival outcomes with manageable toxicities in patients with LA\u2010NSCLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70223","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T17:19:24Z","timestamp":1765819164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic resonance\u2010guided split\u2010course hypo\u2010fractionated radiotherapy with concurrent chemotherapy and consolidative immunotherapy in locally advanced non\u2013small cell lung cancer: A single arm, phase 2 study"],"prefix":"10.1002","volume":"131","author":[{"given":"PengXin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DaQuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShaoHan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Radiology State Key Laboratory of Oncology in South China 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