{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:52:24Z","timestamp":1792666344760,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020295","name":"Natera Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Circulating tumor DNA (ctDNA) is a valuable biomarker for assessing treatment response and molecular residual disease. In advanced esophageal and gastric cancer (gastroesophageal cancer [EGC]), ctDNA dynamics remain poorly understood. The authors investigated ctDNA in patients with advanced EGC to evaluate its clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a multi\u2010institutional, retrospective analysis of 200 patients with recurrent\/metastatic EGCs who underwent commercial ctDNA testing using a personalized, tumor\u2010informed assay (Signatera; Natera, Inc.). Patients were divided into cohort A (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a036; stage I\u2013III with recurrence) or cohort B (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0164; metastatic at diagnosis). Longitudinal ctDNA dynamics were correlated with clinical and radiographic findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In cohort A, 31 of 36 patients (86.1%) had ctDNA collected \u226490 days before recurrence; of these, 25 of 31 patients (80.65%) were ctDNA\u2010positive before recurrence. In cohort B, baseline ctDNA was available for 29 of 164 patients (17.68%), and all 29 were ctDNA\u2010positive. Among 52 patients who had on\u2010treatment ctDNA assessments, 62 treatment lines were analyzed (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a06 in cohort A;\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a046 in cohort B). All who remained ctDNA\u2010negative throughout treatment (Neg\u2010Neg) showed treatment benefit (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06 of 6). Those who converted to ctDNA\u2010positive (Neg\u2010Pos) progressed (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02 of 2). Among ctDNA\u2010positive patients (Pos\u2010Pos), 27 of 40 (67.5%) showed treatment benefit, whereas 13 of 40 (32.5%) progressed. Patients who cleared ctDNA (Pos\u2010Neg) had favorable outcomes (12 of 14 patients; 85.7%). A decrease &gt;90% in ctDNA levels among Pos\u2010Pos patients was linked to superior progression\u2010fee survival. Grouping treatment lines into\n                      <jats:italic>favorable<\/jats:italic>\n                      (Neg\u2010Neg, Pos\u2010Neg, and Pos\u2010Pos with &gt;90% decrease) versus\n                      <jats:italic>unfavorable<\/jats:italic>\n                      (Neg\u2010Pos and Pos\u2010Pos with a &lt;90% decrease or an increase) had significantly improved progression\u2010free survival in the favorable group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ctDNA dynamics predicted progression and may guide treatment or imaging. ctDNA offers a minimally invasive, cost\u2010effective adjunct to radiographic surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70242","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T10:02:53Z","timestamp":1767520973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Circulating tumor DNA informs clinical practice in patients with recurrent\/metastatic gastroesophageal cancers"],"prefix":"10.1002","volume":"132","author":[{"given":"Rutika","family":"Mehta","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine Weill Cornell Medicine\/New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Rivero\u2010Hinojosa","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4970-5189","authenticated-orcid":false,"given":"Farshid","family":"Dayyani","sequence":"additional","affiliation":[{"name":"Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Shariff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H. Lee Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily N.","family":"Aushev","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griffin L.","family":"Budde","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-9171","authenticated-orcid":false,"given":"J. Bryce","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giby V.","family":"George","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2985-3053","authenticated-orcid":false,"given":"Adham A.","family":"Jurdi","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minetta C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Natera, Inc.  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Drengler","sequence":"additional","affiliation":[{"name":"Medical Oncology The START Center for Cancer Care  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Klempner","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Cancer Facts & Figures 2024","author":"American Cancer Society","year":"2024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)32557\u20101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1112088"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(13)61719\u20105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(23)02033\u20100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(21)00797\u20102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002465\u20107"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(23)00620\u20107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(14)70420\u20106"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1425"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.15386\/cjmed\u2010409"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae155"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201018\u20103663"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/po.22.00420"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2024.01.017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003254\u20106"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0528"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2200075"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062056\u20107"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006699"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2024.2727"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2023.4395"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.07.026"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878\u20100261.13557"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.9022"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759\u20107714.14610"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.cd\u201020\u20101408"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.05.114"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.70242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:22:36Z","timestamp":1786796556000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.70242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1002\/cncr.70242"],"URL":"https:\/\/doi.org\/10.1002\/cncr.70242","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2025-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70242"}}