{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:50:16Z","timestamp":1773877816396,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201017\u20102\u20100043"],"award-info":[{"award-number":["W81XWH\u201017\u20102\u20100043"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH2220021"],"award-info":[{"award-number":["W81XWH2220021"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Germline pathogenic variants can inform targeted therapy for metastatic prostate cancer (mPC), and improve cancer early detection and risk reduction for family members. Guidelines recommend germline genetic testing be offered to all men with mPC, yet uptake of testing is only 10%\u201312%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study enrolled veterans participating in the VA Million Veteran Program (MVP) with a diagnosis of mPC. Veterans were contacted by mail with option to opt\u2010out of future contact. Eligible veterans who did not opt\u2010out were mailed study information and received a follow\u2010up phone call to establish interest in germline testing. Participants provided verbal consent and were mailed a saliva collection kit for a CLIA\u2010level multigene cancer predisposition gene panel test. Results were disclosed to the patient and oncology provider. All steps were performed with genetic counseling support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2104 eligible patients, 1952 veterans with mPC did not opt out. Of these, 681 (35%) provided consent and 459 (24%) completed testing. Of those who were approached 63% were White and 25% were Black. Fifty\u2010nine (13%) of those completing testing carried a germline pathogenic variant in a cancer risk gene. Of the 37 eligible for targeted therapy, 14 received targeted therapy, 18 did not yet have an indication for that therapy, and five were deceased without having received targeted therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Participant completion of remote germline testing was facilitated at rates higher than the 10% previously reported. Remote genetic testing can augment uptake of testing in large, integrated health care systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70283","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:46:36Z","timestamp":1769784396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remote delivery of cancer genetic testing in veterans with metastatic prostate cancer: A Million Veteran Program pilot study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4459-0295","authenticated-orcid":false,"given":"Bruce","family":"Montgomery","sequence":"first","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"},{"name":"University of Washington  Seattle Washington USA"},{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-2127","authenticated-orcid":false,"given":"Julie A.","family":"Lynch","sequence":"additional","affiliation":[{"name":"VA Informatics and Computing Infrastructure VA Salt Lake City Health Care System  Salt Lake City Utah USA"},{"name":"Division of Epidemiology, Department of Internal Medicine University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Brown","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara N.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Corporal Michael Crescenz VA Medical Center  Philadelphia Pennsylvania USA"},{"name":"Department of Medicine\u2010Hematology\/Oncology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig C.","family":"Teerlink","sequence":"additional","affiliation":[{"name":"VA Informatics and Computing Infrastructure VA Salt Lake City Health Care System  Salt Lake City Utah USA"},{"name":"Division of Epidemiology, Department of Internal Medicine University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nismeta","family":"Kabilovic","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Stoll","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"},{"name":"Genetic Support Foundation  Olympia Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Simon","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"},{"name":"Genetic Support Foundation  Olympia Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kogan","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajida","family":"Hassan","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3472-3464","authenticated-orcid":false,"given":"Stacey B.","family":"Whitbourne","sequence":"additional","affiliation":[{"name":"Department of Medicine, Million Veteran Program Coordinating Center Veterans Affairs Healthcare System  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumitra","family":"Muralidhar","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Office of Research and Development  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-5553","authenticated-orcid":false,"given":"Martin W.","family":"Schoen","sequence":"additional","affiliation":[{"name":"VA St. Louis Health Care System  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-9638","authenticated-orcid":false,"given":"Rachel","family":"Ramoni","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Office of Research and Development  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Michael","family":"Gaziano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Million Veteran Program Coordinating Center Veterans Affairs Healthcare System  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra O.","family":"Sokolova","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather H.","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle Washington USA"},{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Etzioni","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin C.","family":"Pritchard","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"},{"name":"University of Washington  Seattle Washington USA"},{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Brotman Baty Institute for Precision Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Cancer Institute.Cancer facts: prostate cancer. 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