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Multidisciplinary experts review advances and persistent uncertainties in biomarker\u2010guided assessment, imaging, and systemic therapy for prostate cancer. The discussion outlines priority gaps in evidence that must be addressed to optimize individualized patient care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Workshop topics included use of genomic biomarkers and artificial intelligence\u2010guided tools to identify and manage high\u2010risk and very\u2010high risk localized disease, management of biochemical recurrence, identification of patients with metastatic hormone\u2010sensitive PC who warrant treatment escalation, radiopharmaceutical therapy for metastatic castration\u2010resistant PC including optimal sequencing of approved therapies, role of imaging in identification and management of extraprostatic disease, and lifestyle interventions to optimize survivorship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Many questions remain about management of PC related to biomarker\u2010based risk stratification to guide treatment selection, use of prostate\u2010specific membrane antigen\u2010positron emission tomography, and balancing the risk for PC\u2010related death with risks for treatment\u2010related toxicity. Ongoing research efforts are needed to optimize risk\u2010based treatment, sequence of therapies throughout the disease continuum, and survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70304","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T10:03:52Z","timestamp":1770804232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolving strategies in prostate cancer: Emerging approaches and unmet needs from the Bridging the Gaps in Prostate Cancer expert panel"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-7963","authenticated-orcid":false,"given":"Rana R.","family":"McKay","sequence":"first","affiliation":[{"name":"Genitourinary Oncology, Moores Cancer Center University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0010-8551","authenticated-orcid":false,"given":"Benjamin L.","family":"Maughan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Huntsman Cancer Institute  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia K.","family":"Morgans","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal D.","family":"Shore","sequence":"additional","affiliation":[{"name":"START Carolinas\/Carolina Urologic Research Center  Myrtle Beach South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; 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