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Efforts such as immune RECIST (iRECIST) have adapted these criteria for atypical response patterns seen with immunotherapy, yet the broader temporal and spatial dimensions of progression remain underexplored. Emerging evidence from lung and prostate cancer suggests that not all progression is equivalent: the velocity of disease spread, the tropism or organ site of failure, and the burden of progression each carry prognostic and therapeutic significance. Faster or organ\u2010specific progression can reflect distinct resistance mechanisms, microenvironments, and implications for local versus systemic therapy. Integrating these dimensions into\u00a0clinical trial endpoints\u2014alongside established measures such as time to\u00a0progression, time to next systemic therapy, or post\u2010treatment failure\u2010free survival\u2014could improve interpretability and relevance to clinical decision\u2010making. Prospective, standardized collection of lesion\u2010level and temporal data is essential to validate these approaches and mitigate biases inherent to retrospective analyses. 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