{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:49:15Z","timestamp":1787968155546,"version":"build-2784847793"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07CA168886"],"award-info":[{"award-number":["K07CA168886"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32 CA102618"],"award-info":[{"award-number":["T32 CA102618"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189961"],"award-info":[{"award-number":["UG1CA189961"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interventions for cancer\u2010related cognitive impairment are understudied, particularly during therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with cancer receiving chemotherapy reporting cognitive problems were randomized to one of four study arms for 6 weeks in this phase 2 randomized controlled trial with a 2 \u00d7 2 factorial design. Study arms included: Exercise for Cancer Patients\u00a9\u00ae (EXCAP)\u2013ibuprofen, EXCAP\u2013placebo, ibuprofen only, and placebo only. EXCAP is a home\u2010based, low to moderate\u2010intensity, progressive walking and resistance exercise prescription. Cognitive and biologic assessments were conducted at baseline and post\u2010intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010six participants were randomized (mean age, 53.60; 88.37% female). Between\u2010group analyses showed that participants in the EXCAP\u2013placebo group demonstrated significantly better attention performance on the Trail Making Test\u00a0compared to the placebo group (\u221221.57 seconds,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001; Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a0\u20131.31; 95% CI, \u20132.18 to \u20130.44; lower times indicate better performance). The ibuprofen only group showed greater improvements than the placebo group (\u221211.27\u2010second difference,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05; Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a0\u20130.73; 95% CI, \u20131.57 to 0.11). Both EXCAP\u2013ibuprofen and EXCAP\u2013placebo participants exhibited improvements on the FACT\u2010Cog \u201ccomments from others\u201d compared to placebo (Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a01.00; 95% CI, 0.35 to 1.65 and Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.65; 95% CI, \u20130.01 to 1.31). On Rapid Visual Processing mean latency, participants in the EXCAP\u2010placebo group had a significant improvement compared to placebo (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      = \u22121.10; 95% CI, \u22121.97 to \u22120.23); those receiving ibuprofen had an improvement compared to placebo, which revealed a trend after adjusting for reading score (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      = \u22121.04; 95% CI, \u22122.06 to \u22120.01). The ibuprofen group performed less well on the\u00a0Hopkins Verbal Learning Test\u2010Revised delayed compared to those not receiving ibuprofen (Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a0\u20130.64; 95% CI, \u20131.21 to \u20130.07).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exercise and low\u2010dose ibuprofen improved some domains of cognitive function, although effects were not observed across all measures. Phase 3 trials are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70323","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:01:43Z","timestamp":1776668503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phase 2 trial of exercise and low\u2010dose ibuprofen for cancer\u2010related cognitive impairment in patients receiving chemotherapy"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-7247","authenticated-orcid":false,"given":"Michelle C.","family":"Janelsins","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"},{"name":"Wilmot Cancer Institute  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7731-6298","authenticated-orcid":false,"given":"Riham A.","family":"Alieldin","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3672-1005","authenticated-orcid":false,"given":"Tyler","family":"Holler","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3144-3544","authenticated-orcid":false,"given":"Hongying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Ju","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"},{"name":"Wilmot Cancer Institute  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Shayne","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute  Rochester New York USA"},{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Huston","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute  Rochester New York USA"},{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassandra","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Porto","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamedtaki","family":"Tejani","sequence":"additional","affiliation":[{"name":"Advent Health Cancer Institute  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-8265","authenticated-orcid":false,"given":"Allison","family":"Magnuson","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute  Rochester New York USA"},{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Krebs","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Dunne","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute  Rochester New York USA"},{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya G.","family":"Mohile","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute  Rochester New York USA"},{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Shang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umang","family":"Gada","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-158X","authenticated-orcid":false,"given":"Ajay","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute  Rochester New York USA"},{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram F.","family":"Hezel","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute  Rochester New York USA"},{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus S.","family":"Noel","sequence":"additional","affiliation":[{"name":"Georgetown Lombardi Comprehensive Cancer Center  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok A.","family":"Khorana","sequence":"additional","affiliation":[{"name":"Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Yirinec","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute  Rochester New York USA"},{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dougherty","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim A.","family":"Ahles","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R.","family":"Morrow","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"},{"name":"Wilmot Cancer Institute  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Mustian","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Supportive Care in Cancer University of Rochester  Rochester New York USA"},{"name":"Wilmot Cancer Institute  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"36","article-title":"Cognitive impairment associated with cancer: a brief review","volume":"15","author":"Pendergrass JC","year":"2018","journal-title":"Innov Clin Neurosci"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2013.864260"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010clinpsy\u2010050817\u2010084903"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1387251"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurpra.2017.11.026"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.11.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2018.78.6624"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577769"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010011\u20101158\u20100"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155653"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.01.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21258"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.05.017"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac022"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2023.101655"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae212"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105120"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzz090"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181e0c112"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000002116"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6298"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4370"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160\u2010010\u20109225\u20101"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.43.0116"},{"issue":"1","key":"e_1_2_9_26_1","first-page":"130","article-title":"Exercise, inflammation and aging","volume":"3","author":"Woods JA","year":"2012","journal-title":"Aging Dis"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010022\u201006809\u2010w"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2021.04.013"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz410"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s97864"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282\u2010014\u20100521\u20107"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15951"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.03514"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010016\u20103900\u20102"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010019\u201004772\u20107"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13309"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007056"},{"key":"e_1_2_9_38_1","article-title":"Effects of exercise on cognitive impairment in patients receiving chemotherapy: a multicenter phase III randomized controlled trial","author":"Mustian KM","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3418975"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00083"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208593"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.207449"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078501"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000311269.57716.63"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010020\u201000764\u2010w"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2020.503306"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.564965"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2021.1903488"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.31557\/apjcp.2022.23.6.1847"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010017\u20104013\u20100"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/lgbt.2015.0101"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892\u20100362(96)00027\u2010x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0028\u20103932(98)00036\u20100"},{"key":"e_1_2_9_54_1","volume-title":"Hopkins Verbal LearningTest\u2010Revised Professional Manual","author":"Brandt JBR","year":"2001"},{"key":"e_1_2_9_55_1","unstructured":"CrR:Comprehensive Trail\u2010Making Test professional manual. Austin TX Pro\u2010ed 2002"},{"key":"e_1_2_9_56_1","volume-title":"Controlled Oral Word Association Multilingual Aphasia Examination professional manual","author":"BentonAL H","year":"1978"},{"key":"e_1_2_9_57_1","doi-asserted-by":"crossref","unstructured":"HajjA SalamehP KhouryR et\u00a0al.:Psychometric properties of the 37\u2010item Functional Assessment of Cancer Therapy\u2010Cognitive Function (FACT\u2010Cog) scale in cancer patients.2020","DOI":"10.21203\/rs.3.rs-52087\/v1"},{"key":"e_1_2_9_58_1","volume-title":"ACSM\u2019s guidelines for exercise testing and prescription","author":"American College of Sports Medicine","year":"2018"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00918"},{"key":"e_1_2_9_60_1","first-page":"54","article-title":"Prediction of one repetition maximum (1\u2010RM) strength from a 4\u20106 RM and a 7\u201010 RM submaximal strength test in healthy young adult males","volume":"5","author":"Dohoney P","year":"2002","journal-title":"J Exerc Physiol"},{"key":"e_1_2_9_61_1","volume-title":"Measuring anxiety and anger with the State\u2010Trait Anxiety Inventory (STAI) and the State\u2010Trait Anger Expression Inventory (STAXI)","author":"Spielberger CD","year":"1999"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113218"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae209"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.03.014"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.22.00277"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3138\/ptc\u20102021\u20100032"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30987"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2021.106289"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010020\u201005865\u20104"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010023\u201007220\u20107"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000200817"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.70323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T09:04:00Z","timestamp":1779527040000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.70323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,4,15]]}},"alternative-id":["10.1002\/cncr.70323"],"URL":"https:\/\/doi.org\/10.1002\/cncr.70323","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"2025-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70323"}}