{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:22:14Z","timestamp":1775539334104,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    More than half of endometrial cancer diagnoses can be attributed to obesity. A purely molecular classification in endometrial cancer hampers further understanding of the impact of patient macroenvironment as a major risk factor. The relationship between patient factors, such as age, body mass index (BMI), comorbidity, and ethnicity, and molecular subgroups was studied in a publicly available data set (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0225) and two multicenter European cohorts (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0223;\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0946). Age at diagnosis was highest in the\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutated subgroup, and differed significantly between molecular subgroups. Patients with obesity were younger at diagnosis compared to their lean counterparts across all molecular subgroups (61.9 vs. 66.2 years;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01). Survival was worst in the\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutated subgroup but improved with increasing BMI, which resulted in nonsignificant differences from other subgroups when BMI was &gt;35. These data underscore that patient factors remain important, and their integration with molecular factors needs to be better understood to ultimately improve treatment and prevention strategies in endometrial cancer.\n                  <\/jats:p>","DOI":"10.1002\/cncr.70333","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:43:47Z","timestamp":1773013427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of the patient macroenvironment on molecular subgroups in endometrial cancer"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-8369","authenticated-orcid":false,"given":"Henrica M. J.","family":"Werner","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"GROW\u2013Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederiek A. H.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Faculty of Health Medicine and Life Sciences Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie W.","family":"Vrede","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk A. S.","family":"van den Bosch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"GROW\u2013Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-2570","authenticated-orcid":false,"given":"Marike S.","family":"Lombaers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Asberger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Freiburg University Hospital  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Huvila","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Snijders","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Canisius Wilhelmina Hospital  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Tubita","sequence":"additional","affiliation":[{"name":"Biomedical Research Group in Gynecology Vall d'Hebron Institute of Research  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma Mancebo","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hospital del Mar  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7201-6605","authenticated-orcid":false,"given":"Xavier","family":"Matias\u2010Guiu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Genetics and Research Laboratory CIBERONC IRBLleida University of Lleida Hospital Universitari Arnau de Vilanova  Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Bretov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University Hospital Brno and Masaryk University  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"ENITEC Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit","family":"Weinberger","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University Hospital Brno and Masaryk University  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna M. 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