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This study evaluated the efficacy of a couple\u2010based sexual QOL intervention adapted for MBC couples in a randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010five female MBC patients reporting sexual concerns and their intimate partners (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0110 participants) were randomized to Adapted Intimacy Enhancement (AIE), a four\u2010session videoconference intervention providing education and skills training for coping with sexual\/intimacy concerns, or Enhanced Care\u2010As\u2010Usual (ECAU; informational booklet). Outcomes (measured at baseline, post\u2010intervention, and 6\u2010month follow\u2010up) included patients\u2019 sexual outcomes (sexual function\/distress\/self\u2010efficacy; primary), patients\u2019 psychosocial outcomes (sexual communication, relationship intimacy, and psychological distress; secondary), and similar partner outcomes (secondary). Mixed linear regression models assessed intervention effects on outcomes at follow\u2010ups; psychosocial outcomes were analyzed using dyadic analyses. Effect sizes (Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      ) were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to ECAU, patients in AIE reported greater improvements in overall sexual function (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.018), desire (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.007), and sexual distress (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.046) at 6 months, and in sexual satisfaction at both post\u2010intervention (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.02) and 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Partners in AIE reported greater improvements in sexual distress (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006), sexual self\u2010efficacy (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008), sexual communication (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.004), and relationship intimacy (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01) at 6 months. Effects were largest for patient sexual satisfaction and partner sexual distress at 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared to a detailed informational booklet on sex\/intimacy, the couple\u2010based AIE intervention yielded long\u2010term benefits for MBC patients\u2019 sexual outcomes and partners\u2019 sexual distress and psychosocial outcomes. Future research should identify intervention mediators and optimal dissemination methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70334","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T17:28:39Z","timestamp":1771694919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of a sexual quality of life intervention for couples facing metastatic breast cancer: Results of a randomized controlled trial"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-2407","authenticated-orcid":false,"given":"Jennifer B.","family":"Reese","sequence":"first","affiliation":[{"name":"Cancer Prevention and Control Program Fox Chase Cancer Center  Philadelphia Pennsylvania USA"},{"name":"Department of Social and Behavioral Sciences College of Public Health Temple University  Philadelphia Pennsylvania 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