{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:01:37Z","timestamp":1775642497246,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This first\u2010in\u2010human phase 1 study evaluated the B\u2010cell maturation antigen (BCMA)\u00d7CD3 bispecific antibody WVT078 alone and in combination with the \u03b3\u2010secretase inhibitor WHG626 in patients with relapsed\/refractory multiple myeloma (r\/r MM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The primary objectives were to assess safety, tolerability, and to determine the recommended doses (RDs) and regimens for expansion for WVT078 and WHG626. Secondary objectives included the assessment of preliminary antitumor activity and characterization of pharmacokinetics and immunogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Overall, 56 patients were treated in the dose\u2010escalation part of the study, seven of whom experienced dose\u2010limiting toxicities. Across all dose levels, cytokine release syndrome was the most common treatment\u2010related adverse event. WVT078 monotherapy showed an overall response rate (ORR) of 27.3% and a complete response rate (CRR) of 12.1%. WVT078 combined with WHG626 demonstrated an ORR of 47.8% and a CRR of 21.7%. RDs were not declared, and dose expansion was not initiated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>WVT078 administered with and without WHG626 showed a manageable safety profile. Preliminary activity was observed in patients with r\/r MM. The addition of WHG626 numerically improved response over WVT078 monotherapy. Findings from this study support further evaluation of WHG626 as a combination partner of BCMA\u2010targeting agents for r\/r MM treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70341","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:25:28Z","timestamp":1774459528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Final clinical data of a phase 1 dose\u2010escalation study of WVT078, a BCMA\u00d7CD3 bispecific antibody, alone and in combination with \u03b3\u2010secretase inhibitor WHG626 in patients with relapsed and\/or refractory multiple myeloma"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-0569","authenticated-orcid":false,"given":"Fredrik","family":"Schjesvold","sequence":"first","affiliation":[{"name":"Oslo Myeloma Center, Department of Hematology OSLO University Hospital  Oslo 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