{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:46:16Z","timestamp":1782747976447,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A recent meta\u2010analysis reported that patients with ovarian cancer have a 3\u2010fold increase in the risk of diagnosis of depression compared to the general population. However, the role of disease\u2010related processes in depressive symptoms\u2014particularly at diagnosis versus after treatment\u2014remains unclear. This study aimed to examine the contribution of somatic symptoms to the assessment of depression severity in patients with ovarian cancer, both at diagnosis and 1 year later, compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 428 patients with ovarian cancer completed psychosocial assessments at 1\u20132 weeks before surgical intervention or initiation of neoadjuvant chemotherapy and at a 1\u2010year follow\u2010up visit. A comparison sample from the Midlife in the United States study was included. Item factor analysis was used to examine the functioning of somatic items in a common depression symptom index in both samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Somatic items demonstrated differential functioning between groups. Specifically, patients with ovarian cancer were more likely to endorse somatic symptoms at lower levels of depression as compared to healthy aging adults; they additionally required a lower level of depression to endorse somatic items as compared to nonsomatic items. These differences between patients with cancer and healthy aging adults were no longer present at 1 year postdiagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support the conclusion that somatic symptoms may disproportionately inflate depression scores among patients with ovarian cancer at diagnosis, which may potentially lead to misclassification or overestimation of depression severity. This highlights the need for refined measurement approaches that account for the somatic burden of cancer in assessing depression during active disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70344","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:01:12Z","timestamp":1778482872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rethinking depression diagnosis in ovarian cancer: The role of somatic symptoms"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0327-8326","authenticated-orcid":false,"given":"Rachel","family":"Telles","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain Sciences University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premal H.","family":"Thaker","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Washington University School of Medicine and Siteman Cancer Center  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Goodheart","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center University of Iowa  Iowa City Iowa USA"},{"name":"Department of Obstetrics and Gynecology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-0417","authenticated-orcid":false,"given":"Frank J.","family":"Penedo","sequence":"additional","affiliation":[{"name":"Departments of Psychology and Medicine and Sylvester Comprehensive Cancer Center University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-1762","authenticated-orcid":false,"given":"Anil K.","family":"Sood","sequence":"additional","affiliation":[{"name":"Departments of Gynecologic Oncology and Cancer Biology and Center for RNA Interference and Noncoding RNA University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3793-5881","authenticated-orcid":false,"given":"Susan K.","family":"Lutgendorf","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences University of Iowa  Iowa City Iowa USA"},{"name":"Holden Comprehensive Cancer Center University of Iowa  Iowa City Iowa USA"},{"name":"Department of Obstetrics and Gynecology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2020.02.010"},{"key":"e_1_2_9_3_1","unstructured":"Cancer Stat Facts: Ovarian Cancer.Surveillance Epidemiology and End Results Program. 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